PMID: 9171970May 1, 1997Paper

Post-exercise depression of baroreflex slowing of the heart in humans

Clinical Physiology
L G UlmanM J Morris

Abstract

In normal human subjects, we tested whether a 20- to 30-min period of rhythmic exercise, intended to provoke strong activation of the sympathetic nerves, would lead to prolonged inhibition of vagally mediated bradycardia evoked reflexly by stimulation of the baroreceptors by neck suction. Negative pressure within the neck cuff (-40 to -80 mmHg) reflexly evoked a reproducible increase in pulse interval. Following exercise, this increase in pulse interval was reduced from 444 +/- 104 ms to 76 +/- 57 ms (mean +/- SEM). Recovery time was 42 +/- 9 min. These findings demonstrate a prolonged attenuation of cardiac vagal action following rhythmic exercise in normal human subjects. It is known that neuropeptide Y (NPY) is released from cardiovascular sympathetic nerves, that it attenuates cardiac vagal action and that plasma levels of NPY are elevated for a prolonged period after exercise. Therefore, it is proposed that NPY, released from sympathetic nerves during exercise, attenuates reflexly evoked cardiac vagal action for a prolonged period after exercise ends.

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Citations

Jun 11, 2008·European Journal of Applied Physiology·Omri InbarB J Whipp
Nov 9, 2002·Autonomic Neuroscience : Basic & Clinical·Rowan W L Herbert, Chris P Bolter
Oct 25, 2011·Scandinavian Cardiovascular Journal : SCJ·Lars GullestadBengt Ablad
Nov 18, 2010·Scandinavian Cardiovascular Journal : SCJ·Bengt ÅbladJan M Lundberg
Mar 23, 2011·Hypertension·Christopher K WillieYu-Chieh Tzeng
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Lie GaoIrving H Zucker
Jun 25, 2005·The Journal of Primary Prevention·Jonathan L Shute, Ken Judge
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Lie GaoWei Wang
Oct 1, 2010·Experimental Biology and Medicine·Ann M RasmussonDaniel E Forman
Nov 14, 1998·The American Journal of Physiology·M P ChandlerS E DiCarlo

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