Post-exposure prophylaxis following occupational exposure to HIV and hepatitis B: an analysis of a 12-year record in a Nigerian tertiary hospital

Journal of Infection Prevention
Salisu AbubakarAbdulrazaq Garba Habib

Abstract

Healthcare workers (HCWs) have an increased risk of occupational exposure to blood-borne pathogens. We aim to examine the utilisation and outcome of post-exposure prophylaxis (PEP) for both HIV and hepatitis B (HBV) among HCWs. This was a retrospective study conducted in a tertiary hospital in North-Western Nigeria. We reviewed data on HIV or HBV PEP given to HCWs between 2004 and 2016. A total of 115 HCWs presented for PEP during the study period. Intern doctors were the most exposed group (40/115; 34.8%). There were 86/115 (74.8%) needle stick exposures. While 53/115 (46.1%) of the sources of exposure were HIV-positive, 9/115(7.83%) were HBV-positive. Zidovudine-based regimen (40/70) was the most commonly prescribed. No seroconversion occurred among those that completed PEP treatment and follow-up. No seroconversion occurred among those that received either or both HIV and HBV PEP and completed PEP treatment.

References

Dec 6, 2000·JAMA : the Journal of the American Medical Association·S Johnson, J G Baraboutis
Jan 5, 2001·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·S A WangA Saah
Oct 13, 2001·American Journal of Industrial Medicine·L RudolphK Dervin
Sep 10, 2003·AIDS·Vincenzo PuroUNKNOWN Italian Registry of Antiretroviral Post-Exposure Prophylaxis
Dec 4, 2003·American Journal of Infection Control·Maha TalaatFrank J Mahoney
Jan 15, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shilpa M PatelCharles Bennett
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ingrid V BassettRochelle P Walensky
Nov 22, 2005·American Journal of Industrial Medicine·Annette Prüss-UstünYvan Hutin
Oct 18, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Arno J Dormann, Serhat Aymaz
Jun 7, 2011·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Masoud Sabouri GhannadMohammad Mirzaei
Jul 16, 2014·Lancet·Jean-Philippe GalanaudIsabelle Quéré
Nov 8, 2014·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ljiljana Markovic-DenicDusan Djuric
Apr 25, 2015·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·T M RossouwK L Richter

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Citations

Jan 14, 2020·Chinese Medical Journal·Zun-You Wu, Sarah Robbins Scott
Feb 1, 2020·Therapeutic Advances in Vaccines and Immunotherapy·Farouq Muhammad DayyabAbdulrazaq Garba Habib
Oct 25, 2020·The International Journal of Occupational and Environmental Medicine·Bilkisu Z IliyasuMuktar Hassan Aliyu

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