Post-Extrasystolic Potentiation as a Predictor of Recovery of Left Ventricular Dysfunction After Radiofrequency Catheter Ablation

JACC. Clinical Electrophysiology
Balaji KrishnanVenkatakrishna N Tholakanahalli

Abstract

This study hypothesizes that post-extrasystolic potentiation reflects left ventricle contractile reserve and therefore may predict an improvement of premature ventricular contraction (PVC)-induced cardiomyopathy after PVC ablation. Post-extrasystolic potentiation is a physiologic phenomenon of blood pressure accentuation after a PVC beat. We performed a retrospective study of patients with a PVC burden of ≥10% PVC/24 h and left ventricular ejection fraction (LVEF) of <50% who underwent successful ablation between January 1, 2009, to June 30, 2015. Subjects were classified as having reversible (a final LVEF ≥50%) or irreversible (final LVEF <50%) LV dysfunction on a follow-up echocardiogram. A reference (control) group with ≥10% PVC but normal LV function was also identified. Sixty-one patients (age 68 ± 11 years, 98% male) were studied: 30 with preserved and 31 with reduced LVEF. During median follow-up of 9.4 months, the LVEF of 17 of 31 reduced EF patients improved (reversible) but 14 did not (irreversible). The post-PVC beat systolic blood pressure (SBP) (mm Hg) increase ranged from 12.1 in control subjects (LVEF >50%) to 11.5 in reversible patients to 5 in irreversible patients. In multivariate analysis, the independent pre...Continue Reading

References

Apr 1, 1986·The American Journal of Cardiology·D V UnverferthC V Leier
Dec 1, 1987·The American Journal of Cardiology·W C RobertsB M McManus
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A F Leite-Moreira, J Correia-Pinto
Apr 29, 2006·Journal of Cardiovascular Electrophysiology·Dan WichterleMarek Malik
Feb 1, 2008·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Yumiko KaneiPaul Schweitzer
Mar 30, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Timir S BamanFrank Bogun
Jan 26, 2011·Circulation·Mark H Drazner
Jun 28, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Stavros E MountantonakisFrancis E Marchlinski
May 30, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marc W DeyellFrancis E Marchlinski
Oct 27, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Miki YokokawaFrank Bogun

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Citations

Mar 7, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Gurukripa N KowlgiJose F Huizar
Apr 16, 2021·Progress in Cardiovascular Diseases·Jose F HuizarKenneth A Ellenbogen

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