Abstract
The introduction of genetic approaches in respiratory epidemiology is novel for most epidemiologists, and the post-genome phase poses new challenges. After describing specific questions pertinent to the field of asthma and chronic obstructive pulmonary disease, two main methodological aspects regarding technological and scientific advances are presented in this review. The first one concerns biological aspects in the genome and post-genome phases, i.e. how to study the genome, the transcriptome and the proteome. The second area concerns genetic epidemiology, considering design (case control and family based) and statistical analytical issues. Key aspects are large sample size, good phenotyping and the consideration of environment-by-gene interaction according to windows of opportunity. Needs that have been identified include the following. 1) Networking for setting standards in the field and access to sufficiently large samples. 2) Multidisciplinarity; the collaboration of epidemiologists, clinicians, geneticists and specialists in bioinformatics, in addition to specialists in disciplines less familiar to epidemiologists, to be prepared for new phenotypic characterisations based on transcriptome and proteome. 3) Training in gen...Continue Reading
Citations
Dec 22, 2011·Journal of Clinical Bioinformatics·Hong Chen, Xiangdong Wang
Oct 22, 2010·Environmental Health Perspectives·Jason D SacksMary Ross
Jun 28, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Márton KeszeiCsaba Szalai
Feb 28, 2009·Archivos de bronconeumología·Judith Garcia-AymerichUNKNOWN en nombre del Grupo de Trabajo sobre la Caracterización Fenotípica y Evolución de la Enfermedad Pulmonar Obstructiva Crónica
Jun 10, 2008·Clinics in Chest Medicine·E BargagliPaola Rottoli
Jun 15, 2007·Clinics in Dermatology·Daniel A CulverMani S Kavuru
Nov 1, 2005·Immunology and Allergy Clinics of North America·Michael Kabesch
Apr 5, 2013·Sociology of Health & Illness·Lise Bitsch, Dirk Stemerding
Feb 18, 2011·American Journal of Obstetrics and Gynecology·Amalia S LehmannJamie L Renbarger
Dec 23, 2014·American Journal of Respiratory and Critical Care Medicine·Alvar AgustíJacob I Sznajder
Mar 14, 2007·Respiratory Medicine·Sibylle Bierbaum, Andrea Heinzmann
Nov 30, 2006·Proteomics·Barbara MagiPaola Rottoli
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Ian A YangKwun M Fong
Oct 31, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Wenli ChenHongmei Gao