Post-hoc analysis of a randomized controlled trial on the impact of pre-transplant use of probiotics on outcomes after liver transplantation.

Scientific Reports
M GrątK Zieniewicz

Abstract

Perioperative use of probiotics serves as efficient prophylaxis against postoperative infections after liver transplantation, yet data on long-term effects of pre-transplant probiotic intake is lacking. The aim of this study was to assess the effects of pre-transplant probiotic administration on long-term results of liver transplantation. This was secondary analysis of a randomized trial. Patients were randomized to receive either 4-strain probiotic or placebo before liver transplantation. Five year graft survival was set as the primary end-point. Secondary end-points comprised serum bilirubin and C-reactive protein (CRP) concentration, international normalized ratio (INR), serum transaminases and gamma-glutamyl transferase (GGT) activity. Study group comprised 44 patients, of whom 21 received probiotics and 23 received placebo with 5-year graft survival of 81.0% and 87.0%, respectively (p = 0.591). Patients in the probiotic arm exhibited lower INR (p = 0.001) and CRP (p = 0.030) over the first 6 post-transplant months. In the absence of hepatitis B or C virus infection, pre-transplant administration of probiotics also reduced aspartate transaminase activity (p = 0.032). In the intervention arm, patients receiving probiotics fo...Continue Reading

References

Jan 8, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nada RayesPeter Neuhaus
Sep 13, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Julia B EwaschukKaren L Madsen
Jun 26, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gerardo NardoneAntonio Colantuoni
Mar 26, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Diego RincónRafael Bañares
Mar 3, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M GrątM Krawczyk
Jun 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tarek SawasWon Kyoo Cho
Sep 15, 2016·Gut Pathogens·AbdelRahman Mahmoud AlyRamy K Aziz
Apr 21, 2017·Carcinogenesis·Giovanni BrandiGuido Biasco
May 17, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michał GrątMarek Krawczyk
May 21, 2017·Journal of Hepatology·Reiner WiestRajiv Jalan
Jun 1, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Benjamin HeidrichDietmar Helmut Pieper
Nov 13, 2017·Clinics in Liver Disease·Puneet Puri, Arun J Sanyal
Jan 10, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ting-Chin David ShenVinod K Rustgi
Mar 4, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jasmohan S BajajPatrick M Gillevet
Apr 18, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesca Romana PonzianiVincenzo Mazzaferro
May 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Takako InoueYasuhito Tanaka
May 12, 2018·Nature Reviews. Gastroenterology & Hepatology·Anupriya TripathiRob Knight
May 29, 2018·Pharmacotherapy·Margaret R JorgensonLuis A Fernandez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
M GrątM Krawczyk
Journal of Clinical Gastroenterology
Mary Ellen Sanders
The New Zealand Medical Journal
Gemma Laws, Roslyn Kemp
The American Journal of Clinical Nutrition
Robert J BoyleMimi L K Tang
© 2021 Meta ULC. All rights reserved