Post hoc power analysis: an idea whose time has passed?

Pharmacotherapy
M Levine, M H Ensom

Abstract

Using a hypothetical scenario typifying the experience that authors have when submitting manuscripts that report results of negative clinical trials, the pitfalls of a post hoc analysis are illustrated. We used the same scenario to explain how confidence intervals are used in interpreting results of clinical trials. We showed that confidence intervals better inform readers about the possibility of an inadequate sample size than do post hoc power calculations.

References

Mar 31, 1999·The Behavioral and Brain Sciences·S L Chow
Apr 14, 1999·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·K J Ottenbacher, F Maas
Jun 26, 1999·Annals of Internal Medicine·S N Goodman

❮ Previous
Next ❯

Citations

May 30, 2012·Social Cognitive and Affective Neuroscience·Jeanette A Mumford
Jul 31, 2012·Biomedical Engineering Online·Andreja N KopitarMartin Stefancic
Sep 19, 2001·Pharmacotherapy·J Fogel
Feb 17, 2007·Journal of the American Veterinary Medical Association·Carlos L AragonSteven C Budsberg
Oct 15, 2013·The Journal of Infection·Lilly M VerhagenPeter W M Hermans
Jun 12, 2013·Biochemical Pharmacology·Michael J Marino
Apr 4, 2014·American Journal of Respiratory Cell and Molecular Biology·Samir N P KeladaFrancis S Collins
Feb 19, 2010·Journal of Glaucoma·Elyse Trastman-CarusoRobert Ritch
Aug 31, 2011·The American Journal of the Medical Sciences·Patrick MusondaPhyo K Myint
Nov 6, 2015·Acta Anaesthesiologica Scandinavica·A JohansenA Stubhaug
Mar 4, 2015·Chest·Kathleen A ClarkLawrence C Mohr
Oct 10, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Danilo BruniMaurilio Marcacci
Jan 1, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Tabitha GarweRobert W Letton
Dec 11, 2008·Ophthalmology·David K Wallace, Michele Melia
Mar 10, 2016·Acta Anaesthesiologica Scandinavica·P K HyldmoE Søreide
May 29, 2007·The Annals of Thoracic Surgery·Gary L Grunkemeier, Ruyun Jin
Feb 9, 2007·The Journal of Small Animal Practice·E H HofmeisterS C Budsberg
Dec 15, 2012·The Journal of Comparative Neurology·Corinna Darian-SmithChristina Alarcón
Dec 17, 2009·Developmental Medicine and Child Neurology·Alan S Rigby
Jul 26, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Meghan E RebuliHeather B Patisaul
Apr 24, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Irfahan KassamMichael D Cusimano
Feb 23, 2010·NeuroImage·Jason L SteinUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 1, 2014·Acta Orthopaedica·Tesfaye H LetaOve Furnes
Jul 2, 2015·Thyroid : Official Journal of the American Thyroid Association·Stéphanie Larrivée-VanierJohnny Deladoëy
Mar 15, 2015·Journal of Clinical Psychopharmacology·David L Streiner
Dec 29, 2010·Behavioural Processes·Brianna N GaskillJoseph P Garner
Aug 3, 2011·Contemporary Clinical Trials·Ritesh Maharaj

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Japanese Journal of Clinical Oncology
Morio Sawada, Seiichiro Yamamoto
Texas Medicine
Walt Borges
Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
Tadej Bajd, Marko Munih
The Spine Journal : Official Journal of the North American Spine Society
C F LeeKeith D K Luk
CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Aaron S Kesselheim
© 2021 Meta ULC. All rights reserved