Post-hoc selection of dynamic causal models.

Journal of Neuroscience Methods
M J RosaW Penny

Abstract

Dynamic causal modelling (DCM) was originally proposed as a hypothesis driven procedure in which a small number of neurobiologically motivated models are compared. Model comparison in this context usually proceeds by individually fitting each model to data and then approximating the corresponding model evidence with a free energy bound. However, a recent trend has emerged for comparing very large numbers of models in a more exploratory manner. This led Friston and Penny (2011) to propose a post-hoc approximation to the model evidence, which is computed by optimising only the largest (full) model of a set of models. The evidence for any (reduced) submodel is then obtained using a generalisation of the Savage-Dickey density ratio (Dickey, 1971). The benefit of this post-hoc approach is a huge reduction in the computational time required for model fitting. This is because only a single model is fitted to data, allowing a potentially huge model space to be searched relatively quickly. In this paper, we explore the relationship between the free energy bound and post-hoc approximations to the model evidence in the context of deterministic (bilinear) dynamic causal models (DCMs) for functional magnetic resonance imaging data.

References

Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R B BuxtonL R Frank
Apr 11, 2003·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Darryle Steinberg, Margaret W Beal
Sep 2, 2003·NeuroImage·K J FristonW Penny
Jun 29, 2004·NeuroImage·W D PennyK J Friston
Oct 24, 2006·NeuroImage·Karl FristonWill Penny
Apr 12, 2007·Journal of Biosciences·Klaas E StephanKarl J Friston
Sep 22, 2007·NeuroImage·Justin R ChumbleyStefan J Kiebel
Jun 21, 2008·NeuroImage·Klaas Enno StephanKarl J Friston
Nov 13, 2008·NeuroImage·R J MoranK J Friston
Nov 18, 2008·NeuroImage·André C MarreirosKarl J Friston
Apr 11, 2009·Human Brain Mapping·Stefan J KiebelKarl J Friston
Nov 17, 2009·NeuroImage·K E StephanK J Friston
Jan 13, 2010·Cognitive Psychology·Eric-Jan WagenmakersRaoul Grasman
Nov 26, 2010·Journal of Neuroscience Methods·M PykaA Jansen
Dec 25, 2010·NeuroImage·Karl J FristonKlaas E Stephan
Apr 5, 2011·NeuroImage·Karl Friston, Will Penny

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Citations

Mar 28, 2013·PloS One·William D Penny, Gerard R Ridgway
Nov 21, 2015·NeuroImage·Micah AllenAndreas Roepstorff
Oct 21, 2015·NeuroImage·Shabnam AzadehVeerabhadran Baladandayuthapani
Dec 5, 2015·Frontiers in Human Neuroscience·Lora MinkovaUNKNOWN TrackOn-HD Investigators
Jan 7, 2016·Frontiers in Human Neuroscience·Vladimir LitvakKarl Friston
Nov 17, 2015·NeuroImage·Karl J FristonPeter Zeidman
Jul 23, 2014·Human Brain Mapping·Narges BazarganiIroise Dumontheil
Oct 7, 2015·Frontiers in Behavioral Neuroscience·Laura EnaxBernd Weber
Nov 20, 2014·Frontiers in Behavioral Neuroscience·Roberto LimongiAgustin Ibanez
Jul 12, 2014·Journal of Integrative Neuroscience·Mark Solms
Dec 26, 2008·PLoS Biology·Olivier DavidAntoine Depaulis
Jan 26, 2018·Wiley Interdisciplinary Reviews. Cognitive Science·Stefan FrässleKlaas E Stephan
Aug 4, 2018·Science·Micah G EdelsonTodd A Hare
Mar 16, 2017·Psychometrika·Sacha EpskampDenny Borsboom
Jul 19, 2017·Nature Communications·Lena J TiedemannStefanie Brassen
Nov 19, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yifei WengGuangming Lu
Dec 2, 2020·PLoS Computational Biology·Erik D FagerholmMark P Richardson
Nov 25, 2020·Schizophrenia Research·Florian BitschBenjamin Straube

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Software Mentioned

SPM8
DCM
SPM

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