Post-imprinting and In-Cavity Functionalization

Advances in Biochemical Engineering/biotechnology
Toshifumi TakeuchiYukiya Kitayama

Abstract

Molecularly imprinted polymers (MIPs) are artificial materials capable of molecular recognition for target molecules. Currently MIPs have been prepared without further modification after polymerization, and used for predetermined single purposes. Post-imprinting modifications (PIMs) presented here can provide site-specific modifications within the molecularly imprinted binding cavities after polymerization, enabling MIPs to become more complex functional materials as were the cases of naturally occurring conjugated proteins. We present an overview of the research on MIPs involving PIMs, including transformation of binding sites, on/off switching of binding activity, introduction of desirable functions such as fluorescent signalling functions, catalytic activity, and so on. The combination of PIMs with molecular imprinting appears to be a powerful tool for preparing a diverse range of biomimetic functional materials.

Citations

Aug 10, 2015·Analytical and Bioanalytical Chemistry·Lei Ye
Aug 4, 2016·Tissue Engineering. Part B, Reviews·Mariana I NevesNicholas A Peppas

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