Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice

Cancer Letters
Yoko MatsudaKatsumi Imaida

Abstract

We investigated the effects of bovine LF (bLF) on different phases of NNK-induced lung tumorigenesis in A/J mice. Mice were orally administered 0.02, 0.2 and 2% bLF during the initiation phase, and 2% bLF during the whole tumorigenesis phase or post-initiation phase. Administered bLF during the post-initiation phase showed significant reduction of macroscopical lung nodules, and immunohistochemically decreased expression levels of cell proliferation marker and increased expression levels of apoptosis marker in lung proliferative lesions. bLF might inhibit NNK-induced mouse lung tumorigenesis, only when given limited to the post-initiation phase, through modification of cell proliferation and/or apoptosis.

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Citations

Mar 13, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Min DengGuiyuan Li
Dec 19, 2008·Critical Reviews in Food Science and Nutrition·Lígia RodriguesHelena Lindmark Månsson
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Oct 1, 2016·Pharmaceuticals·Francesco GiansantiGiovanni Antonini
Jul 3, 2021·Cancers·Yuko Nakano-NarusawaYoko Matsuda

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