Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome

Journal of Neurotrauma
Jing ZhaoPramod K Dash

Abstract

Acetylcholine is an excitatory neurotransmitter in the central nervous system that plays a key role in cognitive function, including learning and memory. Previous studies have shown that experimental traumatic brain injury (TBI) reduces cholinergic neurotransmission, decreases evoked release of acetylcholine, and alters cholinergic receptor levels. Galantamine (U.S. Food and Drug Administration approved for the treatment of vascular dementia and Alzheimer's disease) has been shown to inhibit acetylcholinesterase activity and allosterically potentiate nicotinic receptor signaling. We investigated whether acute administration of galantamine can reduce TBI pathology and improve cognitive function tested days after the termination of the drug treatment. Post-injury administration of galantamine was found to decrease TBI-triggered blood-brain barrier (BBB) permeability (tested 24 h post-injury), attenuate the loss of both GABAergic and newborn neurons in the ipsilateral hippocampus, and improve hippocampal function (tested 10 days after termination of the drug treatment). Specifically, significant improvements in the Morris water maze, novel object recognition, and context-specific fear memory tasks were observed in injured animals ...Continue Reading

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Citations

Jul 19, 2019·Journal of Neurotrauma·George EdwardsInes Moreno-Gonzalez
Aug 1, 2020·Frontiers in Neurology·Sagrario ManzanoJavier Olazarán
Feb 28, 2021·Journal of Neurochemistry·Katarzyna WinekAndreas Meisel
May 11, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ari DienelDevin W McBride

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Methods Mentioned

BETA
dissector
enzyme-linked immunosorbent assays
ELISA
electrophoresis
PCR
Assay
enzyme-linked immunosorbent assay

Software Mentioned

EthoVision
ImageJ
SigmaPlot
Systat

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