Post-interventional homocysteine levels: failure as a predictive biomarker of in-stent restenosis

International Journal of Cardiology
F BreuckmannR Erbel

Abstract

Purpose of our study was to determine if homocysteine plasma levels are related to the risk of in-stent restenosis after percutaneous coronary stent implantation in de novo lesions. The putative role of homocysteine as a predictive cardiovascular biomarker of coronary artery disease is well established. The impact of homocysteine levels in the development of in-stent restenosis, however, is controversially discussed. A total of 177 patients with stable angina pectoris undergoing stent implantation in coronary de novo lesions were included. Laboratory determination comprised blood sample evaluation for homocysteine and other conventional risk factors before baseline coronary intervention and prior to six months control catheterization. Binary restenosis, late lumen loss, and late loss index after six months were assessed by quantitative coronary angiography. Endpoints included target lesion and target vessel failure, homocysteine levels as well as major adverse cardiac events. There was a significant correlation between the length of the implanted stent (p<0.006), the percentage of stenosis (p<0.003) and the pre-interventional luminal diameter (p<0.0001) with late loss index. Linear regression analysis demonstrated no significan...Continue Reading

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Feb 6, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Tomohiro OhtsukiHiroaki Shimokawa
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Apr 19, 2020·Journal of Cardiovascular Pharmacology·Shanshan LiXiaofeng Zhao

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