Mar 1, 1981

Post-irradiation thymocyte regeneration after bone marrow transplantation. II. Physical characteristics of thymocyte progenitor cells

Cell and Tissue Kinetics
W BoersmaG van der Westen


Bone marrow cells were separated according to buoyant density, velocity sedimentation and cell surface charge. Fractionated (C3H x AKR)F1 bone marrow cells were transplanted into lethally-irradiated C3H recipients. In all fractions, the CFUs content and the capacity to restore the thymus cell population were determined. For all the physical parameters tested, the thymocyte progenitor cells show the same distribution as CFUs. The relationship between number of thymocyte progenitor cells and number of CFUs is dependent on density. Bone marrow progenitors of PHA responsive cells are of low buoyant density and show a distribution which resembles the distribution of the progenitors of Thy 1 positive cells. After transplantation of large numbers of bone marrow cells into irradiated mice, no significant change in the CFUs content of the thymus was observed.

Mentioned in this Paper

Centrifugation, Density Gradient
Neoplasm of Uncertain or Unknown Behavior of Thymus
Bone Marrow
Lymphocyte Culture Test, Mixed
Surface Properties
Disease of Thymus Gland
Thymic Tissue

About this Paper

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