PMID: 7008946Mar 1, 1981

Post-irradiation thymocyte regeneration after bone marrow transplantation. I. Regeneration and quantification of thymocyte progenitor cells in the bone marrow

Cell and Tissue Kinetics
W J BoersmaG Van der Westen

Abstract

Growth kinetics of the donor-type thymus cell population after transplantation of bone marrow into irradiated syngeneic recipient mice is biphasic. During the first rapid phase of regeneration, lasting until day 19 after transplantation, the rate of development of the donor cells is independent of the number of bone marrow cells inoculated. The second slow phase is observed only when low numbers of bone marrow cells (2.5 x 10(4)) are transplanted. The decrease in the rate of development is attributed to an efflux of donor cells from the thymus because, at the same time, the first immunologically competent cells are found in spleen. After bone marrow transplantation the regeneration of thymocyte progenitor cells in the marrow is delayed when compared to regeneration of CFUs. Therefore, regenerating marrow has a greatly reduced capacity to restore the thymus cell population. One week after transplantation of 3 x 10(6) cells, 1% of normal capacity of bone marrow is found. It is concluded that the regenerating thymus cells population after bone marrow transplantation is composed of the direct progeny of precursor cells in the inoculum.

References

Jan 1, 1985·Immunogenetics·J LesleyR Hyman
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Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Penit, S Ezine
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Citations

May 1, 1976·The Journal of Experimental Medicine·J L Kadish, R S Basch
Feb 28, 1975·Annals of the New York Academy of Sciences·J A HooperA L Goldstein
Feb 1, 1977·The Journal of Experimental Medicine·R S Basch, J L Kadish
Jan 1, 1979·European Journal of Immunology·W J BoersmaG Van der Westen
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Z DarzynkiewiczM R Melamed
Jan 1, 1975·Transplantation·V J WallisA J Davies
Mar 1, 1973·The Journal of Experimental Medicine·M O el-Arini, D Osoba
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J F BachA White
Aug 1, 1973·The Journal of Experimental Medicine·K Komuro, E A Boyse
Oct 1, 1969·Journal of Cellular Physiology·R G WortonJ E TILL
Apr 1, 1970·Journal of Cellular Physiology·J S HaskillM A Moore
Feb 1, 1969·The Journal of Experimental Medicine·J J Owen, M A Ritter
Nov 1, 1961·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·O A TROWELL

Related Concepts

T-Lymphocyte
Colony-Forming Units, Hematopoietic
Spleen
Neoplasm of Uncertain or Unknown Behavior of Thymus
Bone Marrow
Thymocyte
Disease of Thymus Gland
Thymic Tissue
Cell Division Phases
Thymus <angiosperm>

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