PMID: 11912117Mar 26, 2002Paper

Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability

Brain : a Journal of Neurology
Paolo CalabresiGiorgio Bernardi

Abstract

In the present in vitro study of rat brain, we report that transient oxygen and glucose deprivation (in vitro ischaemia) induced a post-ischaemic long-term synaptic potentiation (i-LTP) at corticostriatal synapses. We compared the physiological and pharmacological characteristics of this pathological form of synaptic plasticity with those of LTP induced by tetanic stimulation of corticostriatal fibres (t-LTP), which is thought to represent a cellular substrate of learning and memory. Activation of N-methyl-D-aspartate (NMDA) receptors was required for the induction of both forms of synaptic plasticity. The intraneuronal injection of the calcium chelator BAPTA [bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate] and inhibitors of the mitogen-activated protein kinase pathway blocked both forms of synaptic plasticity. However, while t-LTP showed input specificity, i-LTP occurred also at synaptic pathways inactive during the ischaemic period. In addition, scopolamine, a muscarinic receptor antagonist, prevented the induction of t-LTP but not of i-LTP, indicating that endogenous acetylcholine is required for physiological but not for pathological synaptic potentiation. Finally, we found that striatal cholinergic interneurones, which a...Continue Reading

References

Apr 1, 1992·Trends in Neurosciences·C R Gerfen
Jul 1, 1990·Trends in Neurosciences·A M Graybiel
Nov 1, 1991·The Journal of Physiology·Z G Jiang, R A North
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Jan 1, 1985·Progress in Brain Research·W A Pulsinelli
Nov 1, 1994·Trends in Neurosciences·C HammondY Ben-Ari
Aug 1, 1995·Brain : a Journal of Neurology·P CalabresiG Bernardi
Nov 1, 1993·Journal of Neurophysiology·D M LovingerA Merritt
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Dec 1, 1995·Trends in Neurosciences·Y KawaguchiP C Emson
Feb 1, 1996·Journal of Neurophysiology·V Crépel, Y Ben-Ari
Dec 1, 1995·Journal of Neurophysiology·S Tekkök, K Krnjević
Dec 1, 1995·Current Opinion in Neurobiology·A M Graybiel
Apr 1, 1996·Progress in Neurobiology·J G Greene, J T Greenamyre
Oct 1, 1996·Acta Physiologica Scandinavica·M DrakeT Wieloch
Apr 15, 1996·The Journal of Physiology·J M Auerbach, M Segal
Aug 1, 1997·The Journal of Biological Chemistry·J D English, J D Sweatt
Nov 5, 1997·Trends in Neurosciences·D E Pellegrini-GiampietroR S Zukin
Sep 15, 1998·Trends in Neurosciences·H DanielF Crépel
Feb 5, 1999·Progress in Brain Research·I J Reynolds

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Citations

Apr 29, 2006·Pflügers Archiv : European journal of physiology·Heike FrankePeter Illes
Jun 1, 2005·Studies in History and Philosophy of Biological and Biomedical Sciences·William Bechtel, Adele Abrahamsen
Sep 25, 2003·Lancet Neurology·Paolo CalabresiGiorgio Bernardi
Jan 13, 2012·Journal of Neurophysiology·Nadezhda V Povysheva, Jon W Johnson
Dec 10, 2009·European Journal of Anaesthesiology·Robert D Sanders, Mervyn Maze
Sep 22, 2010·Experimental Neurology·Veronica GhiglieriBarbara Picconi
Nov 15, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sara ArcangeliPaolo Calabresi
Oct 25, 2008·Behavioural Brain Research·Massimiliano Di FilippoPaolo Calabresi
Mar 25, 2008·Neuropharmacology·Massimiliano Di FilippoPaolo Calabresi
Mar 21, 2007·Trends in Neurosciences·Paolo CalabresiMassimiliano Di Filippo
May 22, 2007·Neuroscience·M G WallaceT L Ivanco
Jun 5, 2003·Annals of Neurology·Paolo CalabresiGiorgio Bernardi
May 21, 2009·The European Journal of Neuroscience·Veronica GhiglieriPaolo Calabresi
Mar 8, 2006·The European Journal of Neuroscience·Patrice QuintanaDominique Muller
Oct 5, 2006·Journal of Neurochemistry·John Q WangLimin Mao
Feb 1, 2005·Trends in Pharmacological Sciences·Paolo Calabresi, Letizia Maria Cupini
Jul 21, 2004·Cell Calcium·Antonio PisaniPaolo Calabresi
Jul 28, 2010·Molecular and Cellular Neurosciences·Yan LiZao Cheng Xu
Feb 20, 2010·PLoS Computational Biology·Takashi NakanoKenji Doya
Nov 18, 2005·Journal of Neuroscience Methods·Roberto RoizenblattRobert H Chow
Jul 6, 2017·International Journal of Molecular Sciences·Adriana Lo CastroGiovanna D'Arcangelo
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Emilia SaullePaolo Calabresi
Mar 31, 2007·Stroke; a Journal of Cerebral Circulation·Anna TortiglionePaolo Calabresi
Jan 17, 2004·Stroke; a Journal of Cerebral Circulation·Cinzia CostaPaolo Calabresi
Apr 1, 2006·Stroke; a Journal of Cerebral Circulation·Cinzia CostaPaolo Calabresi
Feb 15, 2008·Médecine sciences : M/S·Pascal BenquetUrs Gerber
Nov 15, 2018·Neural Plasticity·Giuseppina MartellaAngelo Quartarone
Dec 27, 2017·Neuroscience and Biobehavioral Reviews·Serena CaverzasioSalvatore Galati

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