Post-marketing surveillance using pharmacy-based cohorts: results of a pilot study

Pharmacoepidemiology and Drug Safety
Carol Louik, Allen A Mitchell

Abstract

To assess the feasibility of recruiting subjects for follow-up studies of drug exposures using pharmacy records but without involving dispensing pharmacists. Working with Eckerd Corporation, a large chain pharmacy, we attempted to enroll subjects taking either hyoscyamine (Levsin and others) or dicyclomine (Bentyl and others). Adults who filled prescriptions during the recruitment period were randomly assigned to one of four enrollment approaches that used a script and materials we provided: (1) an introductory phone call from an Eckerd pharmacy technician with an offer of a $5 payment; (2) an introductory phone call with no payment; (3) a questionnaire mailed from Eckerd with introductory letters enclosed and an offer of a $5 payment and (4) the same mailed packet but with no payment offered. Willing subjects responded directly to us; they received a follow-up questionnaire approximately 6 weeks following enrollment. This method also provided limited information about subjects who chose not to enroll, permitting us to assess the representativeness of the study population. The enrollment rates for the four groups were 35, 22, 21 and 17% respectively. Rates of completion of the follow-up questionnaire were 86, 83, 83 and 79% res...Continue Reading

References

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Citations

Oct 2, 2015·American Journal of Epidemiology·Corey M BenedumMartha M Werler
Apr 26, 2011·American Journal of Obstetrics and Gynecology·Allen A MitchellUNKNOWN National Birth Defects Prevention Study
Aug 18, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Keith W JaggardEric S Ober

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