Post-mortem biochemistry of NSE and S100B: A supplemental tool for detecting a lethal traumatic brain injury?

Journal of Forensic and Legal Medicine
Monique SieberBenjamin Ondruschka

Abstract

Traumatic brain injury (TBI) is a very common entity that leads to numerous fatalities all over the world. Therefore, forensic pathologists are in desperate need of supplemental methodological tools for the diagnosis of TBI in everyday practice besides the standard autopsy. The present study determined post-mortem neuron specific enolase (NSE) and S100 calcium-binding protein B (S100B) levels as biological markers of an underlying TBI in autopsy cases. Paired serum and CSF samples of 92 fatalities were collected throughout routine autopsies. Afterwards, the marker levels were assessed using commercially available immunoassays (ECLIA, Roche Diagnostics). For statistical analysis, we compared the TBI cases to three control groups (sudden natural death by acute myocardial infarction, traumatic death without impact on the head, cerebral hypoxia). Moreover, the TBI cases were subdivided according to their survival time of the trauma. Brain specimens have been collected and stained immunohistochemically against the aforementioned proteins to illustrate their typical cellular staining patterns with an underlying TBI compared to non-TBI fatalities. CSF NSE and S100B levels were elevated after TBI compared to all control groups (p < 0.0...Continue Reading

Citations

Apr 30, 2019·The American Journal of Forensic Medicine and Pathology·Bastien MorleoCristian Palmiere
May 8, 2018·Journal of Neurotrauma·Benjamin OndruschkaJan Dreßler
Jul 29, 2020·International Journal of Legal Medicine·Simone BohnertCamelia-Maria Monoranu
May 20, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Zi-Wei YuXin-Yuan Gao
Sep 1, 2018·International Journal of Legal Medicine·Benjamin OndruschkaJan Dreßler
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enrica RosatoCristian D'Ovidio

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