Jun 29, 2016

Post-mortem molecular profiling of three psychiatric disorders

BioRxiv : the Preprint Server for Biology
Ryne C RamakerR M Myers

Abstract

Background: Psychiatric disorders are multigenic diseases with complex etiology contributing significantly to human morbidity and mortality. Although clinically distinct, several disorders share many symptoms suggesting common underlying molecular changes exist that may implicate important regulators of pathogenesis and new therapeutic targets. Results: We compared molecular signatures across brain regions and disorders in the transcriptomes of postmortem human brain samples. We performed RNA sequencing on tissue from the anterior cingulate cortex, dorsolateral prefrontal cortex, and nucleus accumbens from three groups of 24 patients each diagnosed with schizophrenia, bipolar disorder, or major depressive disorder, and from 24 control subjects, and validated the results in an independent cohort. The most significant disease differences were in the anterior cingulate cortex of schizophrenia samples compared to controls. Transcriptional changes were assessed in an independent cohort, revealing the transcription factor EGR1 as significantly down regulated in both cohorts and as a potential regulator of broader transcription changes observed in schizophrenia patients. Additionally, broad down regulation of genes specific to neurons...Continue Reading

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Mentioned in this Paper

Pathogenic Aspects
EGR1 gene
Morbidity Aspects
Pathogenesis
Prefrontal Cortex
Genes
Schizophrenia
Sequence Determinations, RNA
Autopsy
Transcription, Genetic

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