Post-Mortem MRI and Histopathology in Neurologic Disease: A Translational Approach

Neuroscience Bulletin
Laura E JonkmanWilma D J van de Berg

Abstract

In this review, combined post-mortem brain magnetic resonance imaging (MRI) and histology studies are highlighted, illustrating the relevance of translational approaches to define novel MRI signatures of neuropathological lesions in neuroinflammatory and neurodegenerative disorders. Initial studies combining post-mortem MRI and histology have validated various MRI sequences, assessing their sensitivity and specificity as diagnostic biomarkers in neurologic disease. More recent studies have focused on defining new radiological (bio)markers and implementing them in the clinical (research) setting. By combining neurological and neuroanatomical expertise with radiological development and pathological validation, a cycle emerges that allows for the discovery of novel MRI biomarkers to be implemented in vivo. Examples of this cycle are presented for multiple sclerosis, Alzheimer's disease, Parkinson's disease, and traumatic brain injury. Some applications have been shown to be successful, while others require further validation. In conclusion, there is much to explore with post-mortem MRI and histology studies, which can eventually be of high relevance for clinical practice.

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
May 1, 1988·AJR. American Journal of Roentgenology·J R HesselinkT G Luerssen
Jan 1, 1997·Neurobiology of Aging·M J De LeonH M Wisniewski
Dec 31, 1997·The Journal of Comparative Neurology·A MorelD Jeanmonod
Apr 29, 1998·Brain : a Journal of Neurology·D H MillerH F McFarland
Mar 2, 1999·Brain : a Journal of Neurology·D KiddT Revesz
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·H BenvenisteG A Johnson
May 24, 2001·Current Opinion in Neurology·P M Matthews, D L Arnold
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Aug 20, 2003·Archives of Neurology·Frederik BarkhofPaul van der Valk
Jan 13, 2006·NeuroImage·M Mallar ChakravartyD Louis Collins
May 10, 2006·Archives of Neurology·Liana G ApostolovaPaul M Thompson
Oct 5, 2006·Brain : a Journal of Neurology·Liana G ApostolovaPaul M Thompson
Jul 21, 2007·Journal of Neurosurgery·Kim RijkersEmile A M Beuls
Feb 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Stefan D RoosendaalJeroen J G Geurts
Mar 15, 2008·Brain : a Journal of Neurology·Milos D IkonomovicSteven T DeKosky
Mar 28, 2008·Acta Neuropathologica·Jeanne E BellHans Kretzschmar
Jul 23, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·N R JonesD A Simpson
Sep 26, 2008·Neurobiology of Aging·Liana G ApostolovaMony J de Leon
Apr 24, 2009·Journal of Magnetic Resonance Imaging : JMRI·Mark D MeadowcroftQing X Yang
May 14, 2009·Multiple Sclerosis : Clinical and Laboratory Research·S D RoosendaalJ J G Geurts
Sep 4, 2009·Brain Pathology·Virawudh SoontornniyomkijHarry V Vinters
Dec 5, 2009·Neuroimaging Clinics of North America·L A Massey, T A Yousry
Jul 14, 2010·Archives of Neurology·David PittPetra Schmalbrock
Jan 7, 2011·Neurology·J J G GeurtsUNKNOWN MAGNIMS Study Group
Jan 6, 2012·Neurology·A SeewannJ J G Geurts
Jan 12, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manon BrundelGeert Jan Biessels
Feb 9, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Vinata Vedam-MaiMichael S Okun
Feb 22, 2012·Cerebral Cortex·Arne K SeehausRalf A W Galuske
Mar 23, 2012·Journal of Neuropathology and Experimental Neurology·Thomas G BeachWalter Kukull

❮ Previous
Next ❯

Citations

Mar 8, 2019·Neuroscience Bulletin·Chao MaDick F Swaab
Oct 28, 2019·Neuroscience Bulletin·Tianbai Li, Weidong Le
Sep 22, 2020·Brain Communications·Baayla D C BoonMartijn D Steenwijk
Sep 24, 2020·Neuroscience Bulletin·Leilei ChenJunxia Xie
Sep 30, 2020·Annals of Physical and Rehabilitation Medicine·Clara DebarleVincent Degos
Nov 14, 2020·Neurochemistry International·Ahilya SinghGerald Münch
Apr 8, 2021·Neuroscience Bulletin·Wenhao ZhuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
imaging techniques

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Qing-shi ZengYi Cui
Neuropsychiatric Disease and Treatment
Wellingson Silva PaivaSuely Kazue Marie
The Journal of Neuropsychiatry and Clinical Neurosciences
H A NasrallahS C Olson
© 2022 Meta ULC. All rights reserved