Post-natal patterns of plasma androgen-binding activity in Djungarian (Phodopus sungorus) and golden (Mesocricetus auratus) hamsters

Journal of Reproduction and Fertility
A W GustafsonG G Kwiecinski

Abstract

The binding of sex steroids to plasma proteins was examined in post-natal Djungarian and golden hamsters. With dihydrotestosterone or testosterone as ligands, steady-state polyacrylamide gel electrophoresis revealed 2 androgen binding components in the plasma of young Djungarian hamsters of both sexes. The fast-moving component exhibited a low affinity and high capacity for androgens and corresponded to albumin in stained gels. In contrast, the slow moving component was a beta-globulin with high affinity (Ka = 10(9) M-1) and low capacity for androgens, and was identified as a specific sex steroid-binding protein (SBP; also SHBG). This SBP did not bind oestrogens or corticosteroids and was electrophoretically distinct from corticosteroid-binding globulin (CBG). In addition, this protein did not appear to be of testicular origin because it was present in immature females and in immature males that had been castrated for 8 days. Plasma concentrations of SBP in males as measured by a diethyl-aminoethyl-cellulose binding assay were low at birth, became significantly elevated shortly thereafter when plasma androgen values were also elevated, and subsequently fell to low levels during puberty. These changes follow the same general pat...Continue Reading

Citations

Jul 15, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M P IkonomopoulouK Ibrahim
May 20, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M P IkonomopoulouA J Bradley
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·D A Damassa, J M Cates
Mar 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·D A DamassaA W Gustafson
Oct 28, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Adrien N PhalenNed J Place
Jul 4, 2003·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Toni R PakPei-San Tsai

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