Post-operative recurrence of Crohn's disease: A prospective study at 5 years

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Sara OnaliL Biancone

Abstract

We aimed to prospectively assess whether endoscopic recurrence severity at 1 year in Crohn's disease is predictive of clinical recurrence within 5 years. Clinical recurrence (Crohn's Disease Activity Index>150) was assessed yearly for 5 years in Crohn's disease patients undergoing ileo-colonic resection. At 1 year, recurrence was assessed by colonoscopy (Rutgeerts' score ≥i1 or ≥2i) and small intestine contrast ultrasonography. 40 patients were included (23 males, median age 39 [16-69] years). Clinical recurrence occurred within 5 years in 16 (40%) patients (years 1, 2, 3, 4, 5: 2 [5%]; 10 [25%]; 4 [10%]; 2 [5%]; 4 [10%], respectively). At 1 year, endoscopic recurrence (score≥i1) occurred in 39 (97.5%) patients (score≥i2: 33 [82.5%]). Ultrasound detected lesions compatible with recurrence in 39/40 (97.5%) patients. Endoscopic score at 1 year was correlated with clinical score at 2 years (p=0.007; r=0.41). Endoscopic score at 1 year was higher in patients with (n=10) vs without (n=30) clinical recurrence at 2 years (3 [2-4] vs 2 [0-4]; p=0.003). Higher endoscopic score (>i2) at 1 year was a risk factor for clinical recurrence within 5 years (OR=0.18; 95% CI 0.04-0.71; p=0.008). In Crohn's disease, severity of endoscopic recurren...Continue Reading

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Citations

Jun 25, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Andrea MagarottoFlavio Caprioli
Dec 23, 2017·Inflammatory Bowel Diseases·Firas RinawiAmit Assa
Oct 20, 2019·Paediatric Drugs·Anat Yerushalmy-Feler, Amit Assa
Jul 11, 2019·Digestive Diseases and Sciences·Ji Young Chang, Jae Hee Cheon
Mar 19, 2020·Updates in Surgery·Stefano D'UgoGiuseppe S Sica
Nov 9, 2020·Biology Direct·L PetagnaG S Sica
Nov 17, 2019·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Mirella FraquelliGiovanni Maconi
Jan 12, 2021·Journal of Immunology Research·B SensiA Divizia
Jan 19, 2021·Gastroenterology Research and Practice·S IngallinellaG S Sica
May 24, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lieven PouillonLaurent Peyrin-Biroulet
Jul 4, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marion SchaeferLaurent Peyrin-Biroulet
Apr 22, 2019·Clinical Radiology·N RaoA Plumb
Nov 6, 2021·Langenbeck's Archives of Surgery·Sandra L KavalukasSusan Galandiuk

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