Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease

Frontiers in Neurology
Stacey Li Hi ShingPeter Bede

Abstract

Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive, mechanisms of progression are poorly understood, and the condition is notoriously under-researched. While motor dysfunction is a hallmark feature of the condition, generalized fatigue, sleep disturbance, decreased endurance, neuropsychological deficits, sensory symptoms, and chronic pain are also often reported and have considerable quality of life implications in PPS. The non-motor aspects of PPS are particularly challenging to evaluate, quantify, and treat. Generalized fatigue is one of the most distressing symptoms of PPS and is likely to be multifactorial due to weight-gain, respiratory compromise, poor sleep, and polypharmacy. No validated diagnostic, monitoring, or prognostic markers have been developed in PPS to date and the mainstay of therapy centers on symptomatic relief and individualized rehabilitation strategies such as energy conservation and muscle strengthening exercise regimes. Despite a number of large clinical trials in PPS, no effective disease-modifying pharmacological treatments are currently available.

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Citations

May 16, 2020·Medical Anthropology·Lenore Manderson, Ayo Wahlberg
Apr 12, 2020·Orphanet Journal of Rare Diseases·Pierre-François PradatUNKNOWN French Kennedy’s Disease Writing Group
Jan 11, 2020·Frontiers in Neurology·Peter Bede, Pierre-Francois Pradat
Feb 27, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Stacey Li Hi ShingPeter Bede
Apr 4, 2021·Journal of the Neurological Sciences·Pierre-Francois Pradat
Feb 5, 2021·Pain Reports·Nadine AttalDidier Bouhassira
Jun 28, 2021·Physical Medicine and Rehabilitation Clinics of North America·Angela Samaan, Miguel X Escalon
Jun 28, 2021·Physical Medicine and Rehabilitation Clinics of North America·John Y Rhee, Kate Brizzi
Sep 11, 2021·Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·David GebauerAndreas Sandner-Kiesling

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Methods Mentioned

BETA
biopsies
biopsy
cognitive behavioral therapy

Software Mentioned

Bi
PAP

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