PMID: 7541970May 25, 1995Paper

Post-polio syndrome spinal cord pathology. Case report with immunopathology

Annals of the New York Academy of Sciences
D C Miller

Abstract

Post-polio syndrome (PPS) describes the clinical onset of progressive muscular weakness many years after survival of acute paralytic poliomyelitis, often in muscle groups clinically unaffected by the original disease process. Prior pathologic descriptions of this often disabling, but not usually fatal, syndrome have been scanty. These have emphasized the presence of persistent or new inflammation in the meninges, spinal cord, and muscles of affected patients. The inflammation suggests several pathogenetic hypotheses, including persistent active poliovirus infection, autoimmune attack on central and peripheral nervous system elements, or increased vulnerability of poliovirus-damaged tissue to new infections. We have recently examined the central nervous system from a PPS patient. The cord showed focal perivascular intraparenchymal chronic inflammatory infiltrates. Immunoperoxidase staining demonstrated that the infiltrates were virtually pure populations of B lymphocytes (immunopositive with antibody L26, and immunonegative with the T cell marker UCHL1 as well as the macrophage marker HAM56). There were rare macrophages (HAM56 immunopositive) and no T cells. The character of the infiltrates suggests that PPS could be an autoimmu...Continue Reading

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Citations

Aug 6, 2019·Frontiers in Neurology·Stacey Li Hi ShingPeter Bede
Jun 8, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Takayuki KosakaHitoshi Takahashi
Nov 28, 2015·Viruses·Hsing-I Huang, Shin-Ru Shih
Nov 25, 2004·Physical Medicine and Rehabilitation Clinics of North America·Matthew N Bartels, Akiko Omura
May 23, 2006·Lancet Neurology·Henrik GonzalezKristian Borg
Mar 23, 2004·Revue neurologique·P Clavelou
Sep 21, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Akiyo HinenoYoshiki Sekijima

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