Abstract
Since the approval of sorafenib, no other agent has been proven to show survival benefits in clinical trials involving patients with advanced hepatocellular carcinoma (HCC) resistant to sorafenib. Prognostic factors for survival after tumor progression in sorafenib-treated patients are critical for designing second-line trials. To determine the factors affecting the post-progression survival (PPS) after sorafenib treatment, additional analyses were conducted using fixed data obtained from our previous prospective study. Data on patients with advanced HCC treated with sorafenib were analyzed in view of patient characteristics at the time of tumor progression and the progression pattern (intra-/extrahepatic growth or emergence of new intra-/extrahepatic lesions). Of the 89 enrolled patients, 70 were diagnosed with disease progression according to the Response Evaluation Criteria in Solid Tumors version 1.1. Multivariate Cox's regression analysis revealed that Child-Pugh scores of ≥7, macrovascular invasion (MVI), and alpha-fetoprotein of >400 ng/mL were independent predictors of poor PPS. Although both extrahepatic metastasis (EHM) and MVI were characteristics of advanced HCC, EHM was not determined as a prognostic factor. Additi...Continue Reading
References
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Dec 20, 2008·The Lancet Oncology·Ann-Lii ChengZhongzhen Guan
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Sep 10, 2009·Cell·Mark ShackletonSean J Morrison
Sep 10, 2010·Hepatology International·Masao OmataShiv Kumar Sarin
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Aug 11, 2011·Digestive Diseases·Masatoshi KudoUNKNOWN HCC Expert Panel of Japan Society of Hepatology
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Jun 22, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maria ReigJordi Bruix
Aug 28, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip J JohnsonAnn-Lii Cheng
Aug 28, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Josep M LlovetJoong-Won Park
Oct 2, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ann-Lii ChengEric Raymond
Jul 25, 2014·JAMA : the Journal of the American Medical Association·Andrew X ZhuLi-Tzong Chen
Nov 28, 2014·Oncology·Masatoshi KudoTetsuya Minami
Dec 10, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Calin CainapSaied El-Nowiem
Dec 17, 2014·Oncology·Hiroyuki OkuyamaTakuji Okusaka
Apr 12, 2015·Investigational New Drugs·Sadahisa OgasawaraOsamu Yokosuka
Jun 23, 2015·The Lancet Oncology·Andrew X ZhuUNKNOWN REACH Trial Investigators
Citations
Aug 19, 2016·PloS One·Sadahisa OgasawaraOsamu Yokosuka
Apr 16, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ann-Lii ChengRonnie T P Poon
Sep 12, 2017·Investigational New Drugs·Sadahisa OgasawaraNaoya Kato
Apr 25, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuji Eso, Hiroyuki Marusawa
May 4, 2018·Oncology·Teiji KuzuyaHidemi Goto
Oct 15, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marco Sanduzzi-ZamparelliMaría Reig
Apr 30, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Teiji KuzuyaMitsuhiro Fujishiro
Dec 20, 2019·Thyroid : Official Journal of the American Thyroid Association·Chie MasakiKoichi Ito
Mar 27, 2020·Cancers·Aya TakahashiYoshito Itoh
Oct 4, 2017·Oncotarget·Pei YuLing-Yi Kong
Jan 5, 2017·World Journal of Hepatology·Jean-Luc RaoulJulien Edeline
Mar 14, 2020·Cardiovascular and Interventional Radiology·Manuel de la Torre-AláezBruno Sangro
Aug 10, 2017·Oncology Letters·Ying-Fen HongXiang-Yuan Wu
Jun 28, 2019·Hepatic Oncology·Jean-Luc RaoulMarine Gilabert
Oct 19, 2019·Cell Death & Disease·Zhengzhao LiJianfeng Zhang
Jun 10, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Wenbo GuoSong Chen
Nov 15, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Maria ReigAndrew X Zhu
Dec 4, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Makoto ChumaShin Maeda
May 15, 2021·Canadian Journal of Gastroenterology & Hepatology·Farshid FathiAbbas Rezaei
Aug 22, 2021·Current Opinion in Pharmacology·Sergio Muñoz-MartínezMaria Reig