Post-progression survival in patients with advanced hepatocellular carcinoma resistant to sorafenib

Investigational New Drugs
Sadahisa OgasawaraOsamu Yokosuka

Abstract

Since the approval of sorafenib, no other agent has been proven to show survival benefits in clinical trials involving patients with advanced hepatocellular carcinoma (HCC) resistant to sorafenib. Prognostic factors for survival after tumor progression in sorafenib-treated patients are critical for designing second-line trials. To determine the factors affecting the post-progression survival (PPS) after sorafenib treatment, additional analyses were conducted using fixed data obtained from our previous prospective study. Data on patients with advanced HCC treated with sorafenib were analyzed in view of patient characteristics at the time of tumor progression and the progression pattern (intra-/extrahepatic growth or emergence of new intra-/extrahepatic lesions). Of the 89 enrolled patients, 70 were diagnosed with disease progression according to the Response Evaluation Criteria in Solid Tumors version 1.1. Multivariate Cox's regression analysis revealed that Child-Pugh scores of ≥7, macrovascular invasion (MVI), and alpha-fetoprotein of >400 ng/mL were independent predictors of poor PPS. Although both extrahepatic metastasis (EHM) and MVI were characteristics of advanced HCC, EHM was not determined as a prognostic factor. Additi...Continue Reading

References

Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Sep 10, 2009·Cell·Mark ShackletonSean J Morrison
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Jun 22, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maria ReigJordi Bruix
Aug 28, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip J JohnsonAnn-Lii Cheng
Aug 28, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Josep M LlovetJoong-Won Park
Oct 2, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ann-Lii ChengEric Raymond
Jul 25, 2014·JAMA : the Journal of the American Medical Association·Andrew X ZhuLi-Tzong Chen
Dec 10, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Calin CainapSaied El-Nowiem

❮ Previous
Next ❯

Citations

Apr 16, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ann-Lii ChengRonnie T P Poon
Apr 25, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuji Eso, Hiroyuki Marusawa
Oct 15, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marco Sanduzzi-ZamparelliMaría Reig
Apr 30, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Teiji KuzuyaMitsuhiro Fujishiro
Dec 20, 2019·Thyroid : Official Journal of the American Thyroid Association·Chie MasakiKoichi Ito
Mar 14, 2020·Cardiovascular and Interventional Radiology·Manuel de la Torre-AláezBruno Sangro
Nov 15, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Maria ReigAndrew X Zhu
May 15, 2021·Canadian Journal of Gastroenterology & Hepatology·Farshid FathiAbbas Rezaei
Aug 22, 2021·Current Opinion in Pharmacology·Sergio Muñoz-MartínezMaria Reig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

© 2022 Meta ULC. All rights reserved