Post-radiosurgical edema associated with parasagittal and parafalcine meningiomas: a multicenter study

Journal of Neuro-oncology
Jason P SheehanL Dade Lunsford

Abstract

Stereotactic radiosurgery (SRS) offers a high degree of tumor control for benign meningiomas. However, radiosurgery can occasionally incite edema or exacerbate pre-existing peri-tumoral edema. The current study investigates the incidence, timing, and extent of edema around parasagittal or parafalcine meningiomas following SRS. A retrospective multicenter review was undertaken through participating centers in the International Gamma Knife Research Foundation (previously the North American Gamma Knife Consortium or NAGKC). All included patients had a parafalcine or parasagittal meningioma and a minimum of 6 months follow up. The median follow up was 19.6 months (6-158 months). Extent of new or worsening edema was quantitatively analyzed using volumetric analysis; edema indices were longitudinally computed following radiosurgery. Analysis was performed to identify prognostic factors for new or worsening edema. A cohort of 212 patients comprised of 51.9 % (n = 110) females, 40.1 % upfront SRS and 59.9 % underwent adjuvant SRS for post-surgical residual tumor. The median tumor volume at SRS was 5.2 ml. Venous sinus compression or invasion was demonstrated in 25 % (n = 53). The median marginal dose was 14 Gy (8-20 Gy). Tumor volume c...Continue Reading

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Citations

Feb 6, 2017·Journal of Neurosurgery·Brigitte GatterbauerJosa M Frischer
Aug 8, 2018·Future Oncology·Robin A BuerkiRimas V Lukas
Apr 6, 2017·Neuro-oncology·John P KirkpatrickPaul D Brown
May 24, 2018·Operative Neurosurgery·Joshua LoewensternRaj K Shrivastava
Sep 27, 2019·Neuro-oncology Practice·Eric K NguyenGlenn S Bauman
Jun 1, 2016·Neuro-oncology Practice·Shannon E FoghPhilip V Theodosopoulos
Feb 27, 2021·Journal of Neuro-oncology·Ansley UnterbergerIsaac Yang

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