Post-radiotherapy PET/CT for predicting treatment outcomes in head and neck cancer after postoperative radiotherapy

European Journal of Nuclear Medicine and Molecular Imaging
Yan LiMin Yao


The purpose of this study was to retrospectively review the role of post-treatment (post-tx) FDG-PET/CT scans in patients receiving postoperative intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinomas (HNSCC). Eighty-two patients with HNSCC treated with surgery and postoperative IMRT with or without chemotherapy from October 15, 2008 to December 31, 2014 that had post-tx PET/CT within 6 months of completing IMRT were included. PET/CT was considered positive based on multi-disciplinary review integrating clinical information. Survival analysis was performed using the Kaplan-Meier method. Categorical and continuous predictors of positive post-tx PET/CT were evaluated using Fisher's exact test and logistic regression, respectively. Predictors for survival outcomes were evaluated with log-rank testing. A p ≤ 0.05 was considered statistically significant. Median follow-up was 3.88 years. For all patients, 3-year overall survival (OS) and recurrence-free survival (RFS) were 71.8% and 61.3%, respectively. Patients with positive post-tx PET/CT had worse OS compared to those with negative post-tx PET/CT (log rank p < 0.001). For patients with positive post-tx PET/CT, 3-year OS was 11.2% compared to 89.9% for ...Continue Reading


Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·K K AngL J Peters
May 7, 2004·The New England Journal of Medicine·Jay S CooperUNKNOWN Radiation Therapy Oncology Group 9501/Intergroup
May 7, 2004·The New England Journal of Medicine·Jacques BernierUNKNOWN European Organization for Research and Treatment of Cancer Trial 22931
Aug 16, 2005·International Journal of Radiation Oncology, Biology, Physics·Min YaoJohn M Buatti
Sep 25, 2007·International Journal of Radiation Oncology, Biology, Physics·Stephanie A ShintaniJan L Kasperbauer
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Apr 22, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Heiko SchöderDennis Kraus
Feb 23, 2010·International Journal of Radiation Oncology, Biology, Physics·Benjamin J MoellerDavid L Schwartz
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Aug 20, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Tejpal GuptaAshwini Budrukkar
Feb 26, 2013·International Journal of Cancer. Journal International Du Cancer·Anuj GoenkaNancy Y Lee
Oct 1, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine H ChungQuynh-Thu Le
Mar 24, 2016·The New England Journal of Medicine·Hisham MehannaUNKNOWN PET-NECK Trial Management Group
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
Jan 17, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Musaddiq J AwanMin Yao
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