Post reperfusion syndrome during liver transplantation: From pathophysiology to therapy and preventive strategies

World Journal of Gastroenterology : WJG
Antonio SiniscalchiStefano Faenza

Abstract

This review aims at evaluating the existing evidence regarding post reperfusion syndrome, providing a description of the pathophysiologic mechanisms involved and possible management and preventive strategies. A PubMed search was conducted using the MeSH database, "Reperfusion" AND "liver transplantation" were the combined MeSH headings; EMBASE and the Cochrane library were also searched using the same terms. 52 relevant studies and one ongoing trial were found. The concept of post reperfusion syndrome has evolved through years to a multisystemic disorder. The implications of the main organ, recipient and procedure related factors in the genesis of this complex syndrome are discussed in the text as the novel pharmacologic and technical approaches to reduce its incidence. However the available evidence about risk factors, physiopathology and preventive measures is still confusing, the presence of two main definitions and the numerosity of possible confounding factors greatly complicates the interpretation of the studies.

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Citations

Feb 22, 2017·International Anesthesiology Clinics·Giorgio Della Rocca, Paolo Chiarandini
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Jan 10, 2018·Clinical Transplantation·Rachel HogenAaron Strumwasser
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Sep 22, 2021·Clinical Transplantation·Ignacio Sáez de la FuenteJuan Carlos Montejo González
Oct 30, 2021·ACS Nano·Bilal HussainReza Abdi

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