Post-resection treatment of glioblastoma with an injectable nanomedicine-loaded photopolymerizable hydrogel induces long-term survival

International Journal of Pharmaceutics
Mengnan ZhaoV Préat

Abstract

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. Despite available therapeutic options, the prognosis for patients with GBM remains very poor. We hypothesized that the intra-operative injection of a photopolymerizable hydrogel into the tumor resection cavity could sustain the release of the anti-cancer drug paclitaxel (PTX) encapsulated in poly (lactic-co-glycolic acid) (PLGA) nanoparticles and prevent GBM recurrence. The tumor was resected 13 days after implantation and a pre-gel solution composed of polyethylene glycol dimethacrylate (PEG-DMA) polymer, a photoinitiator and PTX-loaded PLGA nanoparticles (PTX PLGA-NPs) was injected into the tumor resection cavity. A solid gel filling the whole cavity was formed immediately by photopolymerization using a 400 nm light. PTX in vitro release study showed a burst release (11%) in the first 8 h and a sustained release of 29% over a week. In vitro, U87 MG cells were sensitive to PTX PLGA-NPs with IC50 level of approximately 0.010 μg/mL. The hydrogel was well-tolerated when implanted in the brain of healthy mice for 2 and 4 months. Administration of PTX PLGA-NPs-loaded hydrogel into the resection cavity of GBM orthotopic model lead to more than 50% long-t...Continue Reading

Citations

Aug 28, 2019·Pharmaceutics·Anca OnaciuIoana Berindan-Neagoe
Sep 25, 2019·Pharmaceutics·Giuseppe CirilloFrancesca Iemma
Aug 26, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Md AquibBo Wang
Jul 19, 2020·Journal of Biomedical Materials Research. Part a·Bowen TanJinfeng Liao
Nov 16, 2019·Nature Communications·Jongha LeeDae-Hyeong Kim
Dec 6, 2019·Frontiers in Bioengineering and Biotechnology·Andrei BelousovVadim Kumeiko
Aug 6, 2020·Bio-design and Manufacturing·Jai ThakorAli Khademhosseini
Jul 11, 2020·Nature Communications·Eneko AxpeEric A Appel
May 23, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stuart J SmithRuman Rahman
Jul 16, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mengnan ZhaoVéronique Préat
Jan 12, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Soham D ParikhDebra A Mayes
Jul 24, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·C BastiancichB Newland
Jan 20, 2021·ACS Biomaterials Science & Engineering·Florian RaschFabian Schütt
Aug 31, 2021·Advanced Drug Delivery Reviews·Chiara BastiancichRuman Rahman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Thibaut FourniolsFabienne Danhier
Journal of Controlled Release : Official Journal of the Controlled Release Society
Chiara BastiancichFabienne Danhier
Journal of Insurance Medicine
David S Williams
© 2022 Meta ULC. All rights reserved