Post-SSRI Sexual Dysfunction: Preclinical to Clinical. Is It Fact or Fiction?

Sexual Medicine Reviews
Enis Rauf CoskunerElcin Orhan Kaleagasi

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of drug for various psychiatric disorders during the lifespan, including pregnancy, lactation, childhood, and adolescence. Deterioration in sexual functioning is a major and serious adverse effect of SSRIs. There is emerging evidence that SSRIs can have long-lasting effects on sexuality. To summarize the long-lasting effects of SSRIs on sexuality, starting with animal models and continuing with the clinical experience of different investigators. A literature review of relevant publications in PubMed. To assess the long-lasting effects of SSRIs on sexuality. Although the persistent effects of SSRIs on sexuality have been little studied in humans, animal studies suggest that SSRIs might cause permanent sexual dysfunction after ending SSRI exposure at a young age but not in adulthood in rats. There are no prospective randomized controlled trials in humans and the present evidence is derived from case reports, incidental research findings, and experiences of some internet communities. There is some preclinical evidence from animal studies for enduring SSRI-induced sexual dysfunction, but the available clinical information could prevent a clear decision about th...Continue Reading

Citations

May 8, 2018·The International Journal of Risk & Safety in Medicine·David Healy
Mar 17, 2020·The Medical Journal of Australia·Jody Rothmore
Aug 10, 2021·The International Journal of Risk & Safety in Medicine·Alaina StudtAmy M Pearlman
Nov 19, 2021·Expert Opinion on Drug Safety·Katherine Chinchilla AlfaroCorine Ekhart

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