Post-stress facilitation of serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats

Brain Research
Sâmia Regiane Lourenço JocaFrancisco Silveira Guimarães

Abstract

Recent pieces of evidence suggest that the dorsal hippocampus may mediate adaptation to severe and inescapable stress, possibly by the facilitation of serotonergic and/or noradrenergic neurotransmission. Chronic social stress and high corticosteroid levels would impair this coping mechanism, predisposing animals to learned helplessness. To test the hypothesis that increasing serotonin or noradrenaline levels in the dorsal hippocampus would attenuate the development of learned helplessness (LH), rats received inescapable foot shock (IS) and were tested in a shuttle box 24 h latter. Prestressed animals showed impairment of escape responses. This effect was prevented by bilateral intrahippocampal injections of zimelidine (100 nmol/0.5 microl), a serotonin reuptake blocker, immediately after IS. This effect was not observed when zimelidine was administered before or 2 h after IS. Bilateral intrahippocampal injections of desipramine (3 or 30 nmol/0.5 microl), a noradrenaline reuptake blocker, before IS or immediately after it did not prevent LH development. Desipramine (30 nmol) enhanced LH development when injected before IS. These data suggest that poststress facilitation of hippocampal serotonergic, but not noradrenergic, neurotr...Continue Reading

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Citations

Aug 15, 2013·Cell and Tissue Research·Vincenzo MicaleAlexandra Sulcova
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Willie Mark Uren DanielsDaniel Joseph Stein
Nov 22, 2013·Psychopharmacology·Jiansong ZhouLingjiang Li
Oct 16, 2014·Neuroscience and Biobehavioral Reviews·Luiz Carlos SchenbergJeyce Willig Quintino-Dos-Santos
Jul 7, 2007·Stress : the International Journal on the Biology of Stress·Sâmia Regiane Lourenço JocaFrancisco Silveira Guimarães
Sep 8, 2011·Behavioural Brain Research·Vanessa de Paula SoaresSâmia R L Joca
Nov 6, 2013·The European Journal of Neuroscience·Jeyce W Quintino-dos-SantosLuiz C Schenberg
Dec 3, 2014·Behavioural Brain Research·Elisa GonzalesMichelle A Lane
Apr 9, 2014·Behavioural Pharmacology·Vinicius A Hiroaki-SatoSâmia R L Joca

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