Post-stroke atorvastatin treatment reduces neurological deficits and mortality rate in the stroke-prone spontaneously hypertensive rat

The Journal of Pharmacy and Pharmacology
Aska HayashiMasao Sasamata

Abstract

Several large clinical trials have demonstrated that 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors decreased the incidence of stroke independently of their cholesterol-lowering effect. We have investigated the effect of post-stroke treatment with atorvastatin on neurological deficits and mortality in stroke-prone spontaneously hypertensive rats (SHR-SP). The vehicle-treated group showed significantly aggravated neurological deficits compared with those observed on the first day of stroke. In contrast, the post-stroke oral administration of atorvastatin at 3 or 30 mg kg(-1)/day significantly ameliorated these neurological deficits. Atorvastatin improved the survival rate in a dose-dependent manner, with this effect being significant at 30 mg kg(-1)/day. Atorvastatin did not affect blood pressure, heart rate or total cholesterol in SHR-SP at either dose. In contrast, it significantly increased plasma nitric oxide (NO) levels at both doses. These results indicated that post-stroke administration of atorvastatin ameliorated neurological deficits and prolonged survival, which might have resulted from increased plasma NO, apart from its effect on cholesterol level and blood pressure in SHR-SP. In conclusion, this study de...Continue Reading

References

Jul 1, 1977·Japanese Heart Journal·I AkiguchiC Kawai
Jan 1, 1976·Stroke; a Journal of Cerebral Circulation·Y YamoriM Fukase
Nov 1, 1992·The American Journal of Physiology·E MorikawaM A Moskowitz
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·L J Ignarro
Jul 30, 1993·Biochemical and Biophysical Research Communications·T MalinskiD Bohr
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F Zhang, C Iadecola
Aug 1, 1994·The American Journal of Physiology·T DalkaraM A Moskowitz
Feb 1, 1993·Stroke; a Journal of Cerebral Circulation·N OgikuR Ishida
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Nov 22, 1997·Stroke; a Journal of Cerebral Circulation·N Delanty, C J Vaughan
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M EndresJ K Liao
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·S Amin-HanjaniM A Moskowitz
Jul 4, 2001·JAMA : the Journal of the American Medical Association·M A AlbertUNKNOWN PRINCE Investigators
Oct 10, 2002·American Journal of Nephrology·Noako YokotaHamid Rabb
Dec 7, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hedley C A Emsley, Pippa J Tyrrell
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Seinosuke KawashimaMitsuhiro Yokoyama
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Parveen A RashidPhilip M W Bath

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Citations

May 30, 2009·The Journal of Pharmacology and Experimental Therapeutics·Hazem F ElewaSusan C Fagan
Feb 26, 2008·European Journal of Pharmacology·Norihiro KatoSubrina Jesmin
Jun 17, 2011·Clinical Neuropharmacology·Antonio MuscariMarco Zoli

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