PMID: 10392654Jul 7, 1999Paper

Post-stroke depression and functional outcome: a cohort study investigating the influence of depression on functional recovery from stroke

Clinical Rehabilitation
F B van de WegG J Lankhorst


To investigate the influence of depression on functional recovery after stroke. Multicentre cohort study of 85 patients admitted for clinical rehabilitation. A two-stage case-finding procedure was used to identify patients with depression. For the control group, consecutive nondepressed stroke patients were enrolled. Patients were interviewed at 3-6 weeks and six months after stroke onset. Three rehabilitation centres in the vicinity of Amsterdam. Functional outcome was determined by the Functional Independence Measure (FIM) and the Rehabilitation Activities Profile (RAP). The prevalence of depression (35%) was comparable with the findings of earlier studies in other settings. Patients classified as depressed according to DSM III R criteria (American Psychiatric Association Diagnostic and statistical manual of mental disorders) had a significantly lower functional score, both at onset and after follow-up (FIM and RAP). There was, however, no significant difference in functional improvement between the depressed and the nondepressed group. Mean functional improvement in the six patients treated with antidepressants was 30% better than in the untreated (depressed) patients; numbers were too small for the results to attain statist...Continue Reading


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