Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation

Experimental Neurology
Weiguo LiAdviye Ergul

Abstract

Diabetes is associated with increased risk and worsened outcome of stroke. Previous studies showed that male diabetic animals had greater hemorrhagic transformation (HT), profound loss of cerebral vasculature, and poor behavioral outcomes after ischemic stroke induced by suture or embolic middle cerebral artery occlusion (MCAO). Females are protected from stroke until reaching the menopause age, but young females with diabetes have a higher risk of stroke and women account for the majority of stroke mortality. The current study postulated that diabetes is associated with greater vascular injury and exacerbated sensorimotor and cognitive outcome after stroke even in young female animals. Male and female control and diabetic animals were subjected to transient MCAO and followed for 3 or 14 days to assess the neurovascular injury and repair. The vascularization indices after stroke were lower in male diabetic animals with 90-min but not 60-min ischemia/reperfusion injury, while there was no change in female groups. Cognitive deficits were exacerbated in both male and female groups regardless of the injury period, while the sensorimotor dysfunction was worsened in male diabetic animals with longer ischemia time. These results sugge...Continue Reading

Citations

Jun 15, 2019·Neuromolecular Medicine·Ladonya JacksonAdviye Ergul
Sep 17, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P Constant Dit BeaufilsUNKNOWN Endovascular Treatment in Ischemic Stroke (ETIS) Research Investigators
Jun 8, 2021·Wellcome Open Research·Annastazia E LearoydRebecca C Trueman
Feb 25, 2021·CNS & Neurological Disorders Drug Targets·Ghaith A Bahadar, Zahoor A Shah

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