Post-transcriptional controls - adding a new layer of regulation to clock gene expression

Trends in Cell Biology
Marie CiboisLuc Paillard

Abstract

Living organisms undergo biochemical, physiological and behavioral cycles with periods ranging from seconds to years. Cycles with intermediate periods are governed by endogenous clocks that depend on oscillating gene expression. Here we illustrate the modalities and specific functions of post-transcriptional control of gene expression (exerted on pre-mRNAs and mRNAs) in biological clocks through two examples: the circadian clock and the vertebrate somite segmentation clock, an embryonic clock with a period far below a day. We conclude that both constitutive and cyclic post-transcriptional controls underpin clock function.

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Citations

Apr 6, 2011·Genome Biology·Annelie Oswald, Andrew C Oates
Oct 17, 2012·PloS One·Emma K O'CallaghanAndrew N Coogan
Mar 23, 2013·Molecular BioSystems·Henglin SongTianshou Zhou
May 24, 2013·International Journal of Molecular Sciences·Dongni WangJinhu Guo
Sep 13, 2019·G3 : Genes - Genomes - Genetics·Huan MaJinhu Guo

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