Post-transcriptional down-regulation of Toll-like receptor signaling pathway in umbilical cord blood plasmacytoid dendritic cells

Cellular Immunology
Emily CharrierMichel Duval

Abstract

Plasmacytoid dendritic cells (PDCs) from human umbilical cord blood (UCB) produce lower amounts of IFN-α upon TLR stimulation compared with adult counterparts. This difference may play a role in the low graft-versus-host disease rate after UCB transplantation and in the impaired immune response of the neonate to pathogens. Comparing UCB PDC to their adults counterparts, we found that they exhibited a mature surface phenotype and a normal antigen uptake. They upregulated costimulatory molecules upon activation, although with delayed kinetics. Protein, but not ARN, levels of TLR-9, MyD88, IRAK1 and IRF-7, involved in the TLR-9 signaling pathway were reduced. The expression levels of miR-146a and miR-155, known to be involved in the post-transcriptional down-regulation of immune responses, were higher. These data point out a post-transcriptional down-regulation of the TLR-9/IRF-7 signaling pathway in UCB PDC.

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Citations

May 3, 2013·Clinical and Vaccine Immunology : CVI·Yongzhen XiongJindong Ni
Aug 17, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Emily CharrierMichel Duval
Jun 29, 2013·Human Vaccines & Immunotherapeutics·Yongzhen XiongJindong Ni
Jan 7, 2017·Pediatric Research·David N O'DriscollCatherine M Greene
Jul 8, 2014·Immune Network·Sheng YanVera Sau-Fong Chan
Jan 10, 2017·Frontiers in Immunology·Hong-Ren YuKai-Sheng Hsieh
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May 31, 2017·Cancer Immunology, Immunotherapy : CII·Yildian Díaz-RodríguezMichel Duval
Jun 20, 2018·Frontiers in Immunology·Katherine H RestoriElizabeth D Fixman
Jul 10, 2021·Pediatric Research·Jennifer Bermick, Matthew Schaller

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