Aug 1, 1978

Post-transcriptional suppression of globin gene expression in cells transformed by avian erythroblastosis virus

Proceedings of the National Academy of Sciences of the United States of America
A Therwath, K Scherrer


Cells transformed by avian erythroblastosis virus were grown in vitro for up to 5 months. After a few days in culture, synthesis of hemoglobin was undetectable and could not be induced by dimethyl sulfoxide. As shown by globin cDNA hybridization to nuclear and cytoplasmic RNA carried to Crot values of 10(5) moles of nucleotide per liter X sec, globin genes in these cells are transcribed into pre-mRNA, but no trace of globin mRNA appears in the cytoplasm. The implications of this observation for schemes of post-transcriptional regulations and viral transformation are discussed.

Mentioned in this Paper

Transcription, Genetic
Avian Erythroblastosis Virus
Rous-Associated Virus
Avian Leukosis
Cell Differentiation Process
Genomic Hybridization
Poly(A) Tail
Cell Transformation, Viral
Erythroblastosis, Fetal

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