PMID: 6407830Apr 1, 1983Paper

Post-transfusion hepatitis and its association with pooled clotting factors

European Journal of Clinical Microbiology
U SuggW Schneider

Abstract

A prospective study of post-transfusion hepatitis was conducted in 97 adult patients undergoing open heart surgery. Twelve patients developed presumed non-A, non-B hepatitis (five of these were hospitalized and three were jaundiced), and all 12 had received clotting factors from pooled plasma (fibrinogen, factor VIII, factor IX complex) from different manufacturers. Of the remaining 85 patients none received these high risk plasma derivatives and none developed hepatitis. Multiple peak ALT elevation seems to be an indication of development of chronic non-A, non-B hepatitis. In addition to the 12 cases of presumed non-A, non-B hepatitis, nine cases of serological changes related to hepatitis B virus were observed as follows: six early booster reactions of anti-HBs, but not anti-HBc, in anti-HBs and anti-HBc positive persons; one late immunization-like response for anti-HBs and two serological hepatitis B infections without transaminase elevation. Five of the nine cases were also associated with the administration of pooled clotting factors.

References

Sep 22, 1978·JAMA : the Journal of the American Medical Association·M A Hruby, V Schauf
Jul 1, 1979·Annals of Internal Medicine·M BermanE A Jones
Jun 22, 1978·The New England Journal of Medicine·J H HoofnagleH J Zimmerman
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Oct 16, 1980·The New England Journal of Medicine·U SuggR Lissner

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Citations

Apr 1, 1985·European Journal of Clinical Microbiology·G G FrösnerI K Mushahwar
Sep 1, 1993·Acta Oto-laryngologica·V CollettiZ Policante

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