Abstract
A prospective study of post-transfusion hepatitis was conducted in 97 adult patients undergoing open heart surgery. Twelve patients developed presumed non-A, non-B hepatitis (five of these were hospitalized and three were jaundiced), and all 12 had received clotting factors from pooled plasma (fibrinogen, factor VIII, factor IX complex) from different manufacturers. Of the remaining 85 patients none received these high risk plasma derivatives and none developed hepatitis. Multiple peak ALT elevation seems to be an indication of development of chronic non-A, non-B hepatitis. In addition to the 12 cases of presumed non-A, non-B hepatitis, nine cases of serological changes related to hepatitis B virus were observed as follows: six early booster reactions of anti-HBs, but not anti-HBc, in anti-HBs and anti-HBc positive persons; one late immunization-like response for anti-HBs and two serological hepatitis B infections without transaminase elevation. Five of the nine cases were also associated with the administration of pooled clotting factors.
References
Aug 2, 1975·Lancet·J CraskeD Stern
Nov 1, 1975·Lancet·H J AlterY Moritsugu
Mar 13, 1976·Lancet·R G KnodellC J Bell
Nov 11, 1978·Lancet·J CraskeE M Vandervelde
Mar 10, 1979·Lancet·R J WykeR Williams
Sep 22, 1978·JAMA : the Journal of the American Medical Association·M A Hruby, V Schauf
May 1, 1979·The Journal of Infectious Diseases·A TatedaN Ishida
Jul 1, 1979·Annals of Internal Medicine·M BermanE A Jones
Jun 1, 1978·The Journal of Hygiene·J CraskeE M Vandervelde
Jun 22, 1978·The New England Journal of Medicine·J H HoofnagleH J Zimmerman
Oct 27, 1978·Deutsche medizinische Wochenschrift·H OhlmeierI Hoppe
Sep 1, 1978·Journal of Clinical Pathology·J N KatchakiR Brouwer
Aug 3, 1974·Lancet·A M PrinceS J Millian
Jan 23, 1982·Lancet·Y E CossartS L Ismay
Feb 20, 1982·Lancet·U SuggW Schneider
Apr 10, 1982·Lancet·F TremoladaV Gallucci
Apr 1, 1981·Journal of Clinical Microbiology·M RoggendorfR Zachoval
Jan 1, 1981·Journal of Medical Virology·G PastoreG Frösner
Oct 16, 1980·The New England Journal of Medicine·U SuggR Lissner
Apr 23, 1981·The New England Journal of Medicine·R D AachJ Werch
Apr 1, 1982·Gut·G RealdiA Ruol
Jan 1, 1983·Reviews of Infectious Diseases·A M PrinceB Brotman
Citations
Apr 1, 1985·European Journal of Clinical Microbiology·G G FrösnerI K Mushahwar
Sep 1, 1988·Infection·S ZakariaE H el-Raziky
Sep 1, 1993·Acta Oto-laryngologica·V CollettiZ Policante