PMID: 8938539Nov 1, 1996Paper

Post-transfusion hepatitis type B following multiple transfusions of HBsAg-negative blood

Journal of Hepatology
S SaraswatS Naik

Abstract

Post-transfusion hepatitis continues to occur, though with decreasing frequency, even after screening donor blood for HBsAg, anti-HBc, anti-HCV and alanine aminotransferase activity. Data from developing countries on the frequency and type of post-transfusion hepatitis are scarce. We undertook this prospective study to determine the incidence and type of post-transfusion hepatitis at our center after transfusion of blood negative for HBsAg by ELISA. Forty-one patients undergoing open-heart surgery, who had received 3 or more units of HBsAg-negative blood, were followed up. Serum samples of donor units transfused to recipients who developed post-transfusion hepatitis-B were subjected to HBV DNA amplification by the polymerase chain reaction, using two sets of X-gene specific primers which amplified a 250-bp fragment of the HBV DNA. We found that six of the 41 patients (14.6%) developed post-transfusion hepatitis; four of them (66.6%) developed icteric post-transfusion hepatitis B, whereas two (33.3%) developed anicteric post-transfusion hepatitis C. These six recipients received a total of 48 units of blood and 30 of these 48 units could be subjected to HBV DNA amplification by polymerase chain reaction. Eleven donor samples wer...Continue Reading

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Citations

May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YotsuyanagiK Koike
Jan 5, 2002·Indian Journal of Pediatrics·N Choudhury, S Phadke
Jul 23, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Anila Mathan
Feb 26, 2004·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Jean-Pierre Allain
Feb 13, 2003·Transfusion Medicine·T J BrayJ D H Porter
Oct 12, 2002·Transfusion·W Kurt RothErhard Seifried
Nov 19, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Simona UrbaniMassimo Franchini
Apr 8, 2011·World Journal of Gastroenterology : WJG·José Luis LledóSara Ocaña
Dec 31, 2009·Asian Journal of Transfusion Science·Doaa M ElghannamRaghda E Farag
Nov 23, 2006·Journal of Hepatology·Giovanni RaimondoGiovanni Squadrito
Oct 1, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sang Hee Song, Seong Gyu Hwang
Feb 23, 2005·Expert Review of Molecular Diagnostics·Jean-Pierre Allain, Helen Lee
Aug 6, 2008·European Journal of Gastroenterology & Hepatology·Mehmet DemirUğur Ylmaz
May 16, 2013·Hepatitis Monthly·Maryam VaezjalaliHossein Goudarzi

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