PMID: 7015849Jan 1, 1980Paper

Post-transfusion purpura: an enigma of alloimmunization

American Journal of Hematology
P LauR H Aster

Abstract

A patient with post-transfusion purpura is reported. This female patient, sensitized by previous blood transfusion, developed symptomatic thrombocytopenia seven days after a second blood transfusion. A platelet antibody, which had anti-P1A1 specificity, was identified by 51Cr-release assay and by indirect immunofluorescence. Hemorrhage stopped abruptly after plasma exchange therapy. Thrombocytopenia did not recur when the patient was further challenged with P1A1-positive blood and plasma. Anti-P1A1 antibody, detectable by immunofluorescence but not by complement-dependent platelet cytoxicity, persisted in high titer for at least one year after recovery. The heterogeneity and pathogenesis of this clinical syndrome are discussed.

References

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Citations

Jan 1, 1993·Journal of Clinical Apheresis·B C McLeodH G Klein
Nov 17, 1986·Klinische Wochenschrift·C Mueller-EckhardtK Lechner
Mar 22, 1984·The New England Journal of Medicine·K H Shumak, G A Rock
Apr 1, 1985·The American Journal of the Medical Sciences·R G Sheehan
Mar 28, 2006·Transfusion Medicine Reviews·Lawrence D Petz
Nov 1, 1995·The Veterinary Clinics of North America. Small Animal Practice·K A Harrell, A T Kristensen
Jun 30, 2004·American Journal of Hematology·Alison Wakoff Loren, Charles S Abrams
Jan 24, 1998·Critical Reviews in Clinical Laboratory Sciences·L J McCarthyS S Rothenberger
Mar 28, 2019·Laboratory Medicine·Chelsea MilitoMajed A Refaai
Jun 13, 2003·European Journal of Haematology·Karen-Lise WellingLars Heslet
Jun 1, 1987·American Journal of Hematology·T S NijjarL G Israels
Nov 1, 1983·Scandinavian Journal of Haematology·T K GludC Jersild
Nov 1, 1986·British Journal of Haematology·C Mueller-Eckhardt
Apr 15, 2000·Journal of Clinical Apheresis·K M Grima

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