PMID: 7027026Aug 11, 1981Paper

Post-translational carboxylation of preprothrombin

Molecular and Cellular Biochemistry
B C Johnson

Abstract

In summary, in this review on the function of vitamin K in post-translational modification of precursor proteins by carboxylation of certain glutamyl residues, I have tried to cover in particular the recent work on the reaction, the enzymes involved and the mechanisms being considered. In doing this I have also considered vitamin K, its discovery, its functional form and the possible relation of its metabolism to the carboxylation reaction. Equally the various vitamin K-dependent gla-containing proteins currently known have been described. The carboxylation of synthetic small molecule exogenous substrates and the synthesis and metabolism of the products of carboxylation are of great help in studying the reaction. Structural specificity of vitamin K analogs in vivo and in vitro has been compared and the use of various antagonists in vivo and in vitro considered in attempts to gain an understanding of the overall reaction. The reactions subsequent to carboxylation, e.g., the activation of prothrombin to thrombin via serine proteases and the related activation of the other vitamin K-dependent proteins have not been considered in this review. The review has not covered prothrombin or other vitamin K-dependent protein isolation, nor...Continue Reading

References

Feb 22, 1977·Biochimica Et Biophysica Acta·M P Esnouf, C V Prowse
Mar 1, 1978·Archives of Biochemistry and Biophysics·N H Sloane
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N R BachurH Kon
Jun 1, 1979·The Biochemical Journal·T J VisserG Hennemann
Dec 1, 1979·The Journal of Clinical Investigation·D TrauberS Karpatkin
Aug 23, 1976·Biochemical and Biophysical Research Communications·P V HauschkaP M Gallop
Jan 1, 1977·British Journal of Cancer·P HilgardC G Schmidt
Jan 1, 1978·Electroencephalography and Clinical Neurophysiology·D MegirianM Jouvet
Sep 15, 1979·Toxicology and Applied Pharmacology·H SuzukiK Hiraga
May 15, 1979·FEBS Letters·J Stenflo, M Jönsson
Nov 14, 1979·Biochemical and Biophysical Research Communications·R J LevyP Gallop
May 17, 1976·Biochemical and Biophysical Research Communications·J M GirardotB C Johnson
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·T W MunnsR E Olson
Jan 1, 1977·Annual Review of Biochemistry·F L Crane
Feb 28, 1978·Biochemical and Biophysical Research Communications·J J Van Buskirk, W M Kirsch
Oct 30, 1978·Biochemical and Biophysical Research Communications·A S Bhagwat, P V Sane
Apr 1, 1978·The Journal of Tropical Pediatrics and Environmental Child Health·C A TaylorR L Prosterman
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A E Larson, J W Suttie
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P FernlundA Tufvesson
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P A FriedmanA E Griep
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·K KatayamaK Titani
Jan 1, 1977·Physiological Reviews·J W Suttie, C M Jackson
Jan 1, 1977·Annual Review of Biochemistry·J Stenflo, J W Suttie
Jan 1, 1977·Vitamins and Hormones·R E Olson, J W Suttie
Jan 10, 1977·Biochemical and Biophysical Research Communications·J Lowenthal, V Jaeger
Feb 14, 1979·Biochemical and Biophysical Research Communications·J W SuttieD H Rich
Feb 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Hilgard, B Maat
Jan 15, 1979·Analytical Biochemistry·D A MadarR G Hiskey

❮ Previous
Next ❯

Citations

Sep 1, 2005·Journal of Thrombosis and Thrombolysis·Tivadar FenyvesiIngrid Jörg
Sep 1, 1997·Journal of Clinical Anesthesia·K A Songy, A J Layon
Sep 25, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Tivadar FenyvesiJob Harenberg
Jun 15, 1983·Biochemical and Biophysical Research Communications·M GaudryA Marquet
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·B DroletJ Turgeon
Mar 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J W Suttie
May 25, 1988·Journal of Chromatography·B C Johnson
Dec 16, 1986·Biochimica Et Biophysica Acta·A OrtizJ C Gómez-Fernández

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.