PMID: 9425663Jan 13, 1998Paper

Post-translational modification of proteins and the discovery of new medicine

Current Opinion in Biotechnology
R B Parekh, C Rohlff

Abstract

Post-translational modifications are fundamental to processes controlling behaviour, including cellular signaling, growth and transformation. As the molecular basis of protein modifications in normal and disease processes are becoming better defined, so new strategies for designing therapeutic entities to control complex disease processes are emerging.

References

Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·C T SigalM D Resh
Dec 1, 1995·The Journal of Cell Biology·K L BennettA Aruffo
Mar 1, 1996·The Journal of Cell Biology·A BartolazziI Stamenkovic
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·D S PickeringD R Hampson
May 24, 1996·The Journal of Biological Chemistry·M Ding, D D Vandré
Aug 1, 1996·Trends in Biochemical Sciences·M C Faux, J D Scott
Oct 11, 1996·The Journal of Biological Chemistry·J SelzerK Aktories
Nov 15, 1996·The Journal of Biological Chemistry·C S ArnoldG W Hart
Oct 1, 1996·Current Opinion in Neurobiology·J C Martinou, R Sadoul
Dec 1, 1996·Current Opinion in Biotechnology·G A BeaudryM I Sherman
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J P Morello, M Bouvier
Dec 1, 1996·Trends in Neurosciences·L M Schwartz, C E Milligan
Dec 1, 1996·Current Opinion in Structural Biology·L N Johnson, M O'Reilly
Jan 1, 1997·Life Sciences·G J MilczarekG T Bowden
Jan 24, 1997·The Journal of Biological Chemistry·M S Jiang, G W Hart
Jan 1, 1997·Journal of Cellular Biochemistry·D J Livingston
Jan 1, 1997·Journal of Cellular Biochemistry·A Rosen, L Casciola-Rosen
Feb 7, 1997·Cell·T Hunter
Feb 7, 1997·Cell·S Nagata
Jan 1, 1997·Journal of Molecular and Cellular Cardiology·M BeaulieuM Bouvier
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D C Talbot, P D Brown
Mar 1, 1997·The Journal of Clinical Investigation·K Aktories
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·P M Rudd, R A Dwek
Jan 1, 1997·Cancer Immunology, Immunotherapy : CII·K R JeromeO J Finn
Apr 4, 1997·Cell·A V ChervonskyL A Matis
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·J B Gibbs, A Oliff
May 16, 1997·The Journal of Biological Chemistry·U G LopesG M Cooper
May 1, 1997·The Journal of Allergy and Clinical Immunology·A T KotsimbosQ Hamid
May 30, 1997·The Journal of Biological Chemistry·S van DelftP M van Bergen en Henegouwen
Jun 13, 1997·The Journal of Biological Chemistry·P ErhardtG M Cooper
Jun 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Superti-Furga, S Gonfloni
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·H CuiS T Ju
Jun 1, 1997·Antisense & Nucleic Acid Drug Development·R I Glazer

❮ Previous
Next ❯

Citations

Sep 1, 2005·Biomedical Microdevices·David T Eddington, David J Beebe
Mar 14, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rozalina G McCoy, K Sreekumaran Nair
Dec 18, 2001·Trends in Biotechnology·Zhiping Weng, Charles DeLisi
Aug 22, 2000·Parasitology Today·J BarrettP M Brophy
Jul 8, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J StulíkC W Heizmann
May 11, 1999·Drug Discovery Today·M J PageR Parekh
Feb 13, 2007·BMC Bioinformatics·Jason W H WongGerard Cagney
Jul 6, 2000·Bioscience, Biotechnology, and Biochemistry·M MuroiA Takatsuki
Aug 1, 2009·Expert Opinion on Drug Discovery·Lee Harland, Anna Gaulton
Oct 4, 2006·FEBS Letters·José de Jesús PérezJuan Antonio García
May 19, 2011·Chemical Biology & Drug Design·Zhengzhi FangWenbing Yao
Oct 1, 2008·Proteomics. Clinical Applications·Joon-Yong ChungStephen M Hewitt
Jul 5, 2005·Expert Opinion on Investigational Drugs·C R Stubberfield, M J Page
Dec 24, 2013·Antioxidants & Redox Signaling·Michael Lienhard Schmitz, Laureano de la Vega
Apr 10, 2010·Expert Review of Proteomics·Kant M MatsudaStephen M Hewitt
Aug 5, 2003·Journal of Molecular Recognition : JMR·Wlad Kusnezow, Jörg D Hoheisel
Mar 30, 2007·Chembiochem : a European Journal of Chemical Biology·John B BigginsJohn T Koh
Mar 9, 2006·The Journal of Biological Chemistry·Mohan SarkarGabrielle L Boulianne
May 10, 2013·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Beyhan Duran
Jul 4, 2002·Molecular & Cellular Proteomics : MCP·Timothy J GriffinRuedi Aebersold
Nov 5, 2003·The Journal of Biological Chemistry·Christina GewinnerBernd Groner
Jul 26, 2017·Chembiochem : a European Journal of Chemical Biology·Sumana VenkatChenguang Fan
May 13, 2003·The Journal of Biological Chemistry·Pierre S W LeeRik Derynck
Jul 13, 2004·The Journal of Biological Chemistry·Lance WellsGerald W Hart
Nov 18, 2018·Cancer Research·Jung-Mao HsuMien-Chie Hung
Jun 1, 2005·Analytical Chemistry·Karin StadtherrPetra Lindner
Mar 17, 1999·Analytical Biochemistry·J L KerwinJ R Yates
Jul 2, 2021·Matrix Biology Plus·Jared A Mereness, Thomas J Mariani
Dec 13, 2005·Journal of Proteome Research·Maja MatisJasna Peter-Katalinić

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