Post-translational Modification Regulates Formation and Cargo-Loading of Extracellular Vesicles.

Frontiers in Immunology
Jonathan M CarninoYang Jin

Abstract

Accumulating evidence suggests that post-translational modifications (PTMs) regulate the selective encapsulation of non-coding RNA molecules into extracellular vesicles (EVs) and contribute to the downstream functions of EVs or EV-cargo non-coding RNAs. EVs are a newly studied mechanism of intercellular communication that involves the transfer of molecules, including but not limited to proteins, lipids, and non-coding RNAs, to induce functional changes in the recipient cells. In this present mini-review, we focus on the PTM-regulated protein and non-coding RNA selection into eukaryotic EVs.

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Citations

Jan 9, 2021·Developmental Psychobiology·Caroline TrumpffCatherine Monk
Nov 8, 2020·Medical Sciences : Open Access Journal·Kareemah NiYang Jin
Mar 7, 2021·International Journal of Molecular Sciences·Sophie RomeSoazig Le Lay
Mar 19, 2021·Journal of Extracellular Vesicles·Yuefei ZhangYuehai Ke
May 8, 2021·Seminars in Cancer Biology·Ying ZhangHang Yin
May 3, 2021·Molecular Immunology·Janaina Macedo-da-SilvaGiuseppe Palmisano
Aug 12, 2021·FASEB BioAdvances·Andrea SchnatzEva-Maria Krämer-Albers
Aug 10, 2021·Frontiers in Medicine·Jonathan M CarninoYang Jin
Sep 9, 2021·Cell Metabolism·Roi IsaacJerrold M Olefsky
Oct 28, 2021·Advanced Healthcare Materials·Bryan Z WangGordana Vunjak-Novakovic

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Methods Mentioned

BETA
Glycosylation
ubiquitination
sumoylation
protein folding
biopsy
acetylation

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