Post-translational modifications: How to modulate Rab7 functions.

Small GTPases
Graziana Modica, Stephane Lefrancois

Abstract

The small GTPase Rab7 is the main regulator of membrane trafficking at late endosomes. This small GTPase regulates endosome-to-trans Golgi Network trafficking of sorting receptors, membrane fusion of late endosomes to lysosomes, and autophagosomes to lysosomes during autophagy. Rab7, like all Rab GTPases, binds downstream effectors coordinating several divergent pathways. How cells regulate these interactions and downstream functions is not well understood. Recent evidence suggests that Rab7 function can be modulated by the combination of several post-translational modifications that facilitate interactions with one effector while preventing binding to another one. In this review, we discuss recent data on how phosphorylation, palmitoylation and ubiquitination modulate the ability of this small GTPase to orchestrate membrane trafficking at the late endosomes.

References

Sep 20, 1993·FEBS Letters·G JobertyA Zahraoui
Jun 23, 1998·The Journal of Biological Chemistry·J A Duncan, A G Gilman
Apr 14, 2004·The Journal of Cell Biology·Matthew N J Seaman
Apr 14, 2004·The Journal of Cell Biology·Cecilia N ArighiJuan S Bonifacino
Nov 3, 2004·Nature Reviews. Molecular Cell Biology·Suzanne Pfeffer, Dikran Aivazian
May 11, 2005·Traffic·Alessandra d'AzzoTommaso Nastasi
Aug 3, 2005·Nature Reviews. Molecular Cell Biology·Rebecca L WelchmanR John Mayer
Nov 30, 2005·Annals of Neurology·Scott A SmallTae-Wan Kim
Apr 4, 2006·Journal of Lipid Research·David A MitchellRobert J Deschenes
Aug 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bianka L GrosshansPeter Novick
Oct 3, 2006·Methods : a Companion to Methods in Enzymology·Yuko FukataMasaki Fukata
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Maurine E Linder, Robert J Deschenes
Dec 15, 2007·Biochemical and Biophysical Research Communications·Maryssa CanuelCarlos R Morales
Feb 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria Rita SpinosaCecilia Bucci
Nov 5, 2008·The Journal of Cell Biology·Raul RojasJuan S Bonifacino
Mar 7, 2009·The Journal of Biological Chemistry·Phillip A Vanlandingham, Brian P Ceresa
Sep 17, 2009·Biochemical Society Transactions·Laura CogliCecilia Bucci
Apr 27, 2010·Nature Chemical Biology·Frank J DekkerHerbert Waldmann
May 15, 2010·Current Opinion in Cell Biology·Francis Barr, David G Lambright
Jun 1, 2010·Nature Chemical Biology·Yao-Wen WuRoger S Goody
Jan 21, 2011·Physiological Reviews·Alex H Hutagalung, Peter J Novick
Jul 19, 2011·American Journal of Human Genetics·Carles Vilariño-GüellMatthew J Farrer
Jul 19, 2011·American Journal of Human Genetics·Alexander ZimprichTim M Strom
Dec 20, 2011·European Journal of Cell Biology·Justyna KoryckaAleksander F Sikorski
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anja W FjorbackOlav M Andersen
Mar 21, 2012·Molecular and Cellular Biology·Aline MamoStephane Lefrancois
Nov 29, 2012·Journal of Proteome Research·Houjiang ZhouShabaz Mohammed
Feb 6, 2013·The Journal of Cell Biology·Julia BlümerAymelt Itzen
Mar 15, 2013·Biochemical and Biophysical Research Communications·Karine Dumaresq-DoironStephane Lefrancois
Jun 12, 2013·Nature Methods·Philipp MertinsSteven A Carr
Apr 22, 2014·Nature Chemical Biology·Vincent J MecozziScott A Small
Feb 12, 2015·Nature Reviews. Neuroscience·Scott A Small, Gregory A Petsko
Apr 3, 2015·Physiological Reviews·Luke H Chamberlain, Michael J Shipston
Jul 17, 2015·IUBMB Life·Pranita HanpudeTushar Kanti Maiti
Feb 13, 2016·Nature Communications·Swapnil Rohidas Shinde, Subbareddy Maddika
Feb 26, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pingping SongDimitri Krainc
Mar 15, 2016·Frontiers in Aging Neuroscience·Chaosi LiLifeng Yang

❮ Previous
Next ❯

Citations

Mar 13, 2019·Cells·Esther Hui Na Tan, Bor Luen Tang

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
GTPase
ubiquitination
deacylation

Related Concepts

Related Feeds

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.