Post-translational Modifications in Heart Failure: Small Changes, Big Impact

Heart, Lung & Circulation
Ahyoung LeeChangwon Kho

Abstract

Heart failure is a complex disease process with various aetiologies and is a significant cause of morbidity and death world-wide. Post-translational modifications (PTMs) alter protein structure and provide functional diversity in terms of physiological functions of the heart. In addition, alterations in protein PTMs have been implicated in human disease pathogenesis. Small ubiquitin-like modifier mediated modification (SUMOylation) pathway was found to play essential roles in cardiac development and function. Abnormal SUMOylation has emerged as a new feature of heart failure pathology. In this review, we will highlight the importance of SUMOylation as a regulatory mechanism of SERCA2a function, and its therapeutic potential for the treatment of heart failure.

References

Aug 1, 1995·Cardiovascular Research·F del MonteS E Harding
Oct 27, 1997·The Journal of Biological Chemistry·E S Johnson, G Blobel
Dec 31, 1997·FEBS Letters·J M DesterroR T Hay
Jun 6, 1998·Cardiovascular Research·G Hasenfuss
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M I MiyamotoR J Hajjar
Feb 29, 2000·The Journal of Biological Chemistry·H Saitoh, J Hinchey
Oct 5, 2001·Molecular Cell·T KahyoH Yasuda
Jan 17, 2002·Cell·Andrea PichlerFrauke Melchior
Dec 11, 2002·Expert Opinion on Therapeutic Targets·Volker RoenickeThomas Henkel
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Federica del MonteRoger J Hajjar
Jun 11, 2004·Annual Review of Biochemistry·Erica S Johnson
Oct 1, 2004·Molecular Biology of the Cell·Ferhan Ayaydin, Mary Dasso
Dec 2, 2004·Biochimica Et Biophysica Acta·R Jürgen Dohmen
Oct 4, 2005·Biochemical and Biophysical Research Communications·David OwerbachKurt M Bohren
Sep 27, 2006·Molecular & Cellular Proteomics : MCP·Alfred C O VertegaalAngus I Lamond
Feb 16, 2007·Journal of Molecular and Cellular Cardiology·Susumu SakataRoger J Hajjar
Apr 27, 2007·Protein Expression and Purification·Kurt M BohrenDavid Owerbach
May 15, 2007·Circulation Research·Joerg HerrmannAmir Lerman
May 15, 2007·Trends in Biochemical Sciences·Debaditya Mukhopadhyay, Mary Dasso
Aug 19, 2007·Heart·Arend Mosterd, Arno W Hoes
Nov 6, 2007·Trends in Genetics : TIG·Erwin Pauws, Philip Stanier
Nov 15, 2007·Nature Reviews. Molecular Cell Biology·Ruth Geiss-Friedlander, Frauke Melchior
Nov 23, 2007·Biochemical Society Transactions·J Anckar, L Sistonen
Mar 18, 2008·Journal of the American College of Cardiology·Yoshiaki KawaseRoger J Hajjar
Mar 31, 2009·Journal of Cardiac Failure·Brian E JaskiUNKNOWN Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID) Trial Investigators
Sep 4, 2009·The Journal of Clinical Investigation·Martin KruseOlaf Pongs
May 13, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lahouaria HadriRoger J Hajjar
Nov 10, 2010·Nature Reviews. Cardiology·Anh L BuiGregg C Fonarow
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Jaclyn R Gareau, Christopher D Lima
Jan 5, 2011·Journal of Biomedicine & Biotechnology·Chiara V Segré, Susanna Chiocca
Jan 5, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Jun Wang

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Citations

Apr 6, 2019·Journal of Cellular and Molecular Medicine·Kaowen YanPeifeng Li
Dec 7, 2018·Journal of Cellular and Molecular Medicine·Zhen YangShiren Sun
Feb 25, 2021·Pflügers Archiv : European journal of physiology·Xiao-Dong ZhangNipavan Chiamvimonvat
Apr 27, 2021·Journal of Cellular Biochemistry·Zhen ZhangWeidong Zhang
Aug 20, 2021·Frontiers in Cardiovascular Medicine·Ezra B Ketema, Gary D Lopaschuk
Aug 17, 2021·Frontiers in Cardiovascular Medicine·Wei ZhaoJianhui Rong

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