Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV.

Frontiers in Microbiology
Mel Campbell, Yoshihiro Izumiya

Abstract

KSHV latency can be envisioned as an outcome that is balanced between factors that promote viral gene expression and lytic replication against those that facilitate gene silencing and establish or maintain latency. A large body of work has focused on the activities of the key viral regulatory proteins involved in KSHV latent or lytic states. Moreover, recent studies have also begun to document the importance of epigenetic landscape evolution of the KSHV viral genome during latency and reactivation. However, one area of KSHV molecular virology that remains largely unanswered is the precise role of post-translational modifications on the activities of viral factors that function during latency and reactivation. In this review, we will summarize the post-translational modifications associated with three viral factors whose activities contribute to the viral state. The viral proteins discussed are the two major KSHV encoded transcription factors, K-Rta (KSHV replication and transcriptional activator) and K-bZIP (KSHV basic leucine zipper) and the viral latency-associated nuclear antigen (LANA). A special emphasis will be placed on the role of the sumoylation pathway in the modulation of the KSHV lifecycle. Newly uncovered small ubi...Continue Reading

Citations

Nov 28, 2013·PLoS Pathogens·Qiliang CaiErle S Robertson
Jan 17, 2015·Viruses·Pravinkumar PurushothamanSubhash C Verma
Oct 1, 2014·Cancers·Pei-Ching Chang, Hsing-Jien Kung
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Dec 25, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Yuxuan XiaoMargarita Vigodner
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Feb 19, 2021·Frontiers in Cellular and Infection Microbiology·Mila Collados Rodríguez

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Methods Mentioned

BETA
sumoylation
acetylation
acetylating
PARylation
ChIP
two-hybrid
co-immunoprecipitation
affinity column elution

Software Mentioned

GeneSpring GX11

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