Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens.

Microbiome
Jing WangYun Chen

Abstract

Microbiome interactions are important determinants for ecosystem functioning, stability, and health. In previous studies, it was often observed that bacteria suppress potentially pathogenic fungal species that are part of the same plant microbiota; however, the underlying microbe-microbe interplay remains mostly elusive. Here, we explored antagonistic interactions of the fungus Fusarium graminearum and bacterium Streptomyces hygroscopicus at the molecular level. Both are ubiquitous members of the healthy wheat microbiota; under dysbiosis, the fungus causes devastating diseases. In co-cultures, we found that Streptomyces alters the fungal acetylome leading to substantial induction of fungal autophagy. The bacterium secrets rapamycin to inactivate the target of rapamycin (TOR), which subsequently promotes the degradation of the fungal histone acetyltransferase Gcn5 through the 26S proteasome. Gcn5 negatively regulates fungal autophagy by acetylating the autophagy-related protein Atg8 at the lysine site K13 and blocking cellular relocalization of Atg8. Thus, degradation of Gcn5 triggered by rapamycin was found to reduce Atg8 acetylation, resulting in autophagy induction in F. graminearum. Autophagy homeostasis plays an essential r...Continue Reading

References

Dec 2, 2000·Nature·Y IchimuraY Ohsumi
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Aaron Ciechanover
Jan 20, 2007·The Journal of Clinical Investigation·Ravi K AmaravadiCraig B Thompson
Mar 31, 2007·Nature Reviews. Drug Discovery·David C RubinszteinDaniel J Klionsky
Feb 22, 2008·Molecular Biology of the Cell·Tomoko KawamataYoshinori Ohsumi
Jan 7, 2009·The Journal of Biological Chemistry·In Hye Lee, Toren Finkel
Feb 20, 2009·Molecular Biology of the Cell·Chang Hwa JungDo-Hyung Kim
Mar 5, 2009·The Journal of Biological Chemistry·Ian G GanleyXuejun Jiang
Jan 20, 2010·FEBS Letters·Chang Hwa JungDo-Hyung Kim
Mar 30, 2010·Nature Reviews. Microbiology·Anton Y PelegEleftherios Mylonakis
Nov 1, 2004·Molecular Plant Pathology·Rubella S Goswami, H Corby Kistler
Oct 23, 2010·Molecular Cell·Guido KroemerBeth Levine
Feb 1, 2011·Trends in Cell Biology·David G McEwan, Ivan Dikic
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hans-Wilhelm NützmannAxel A Brakhage
Nov 8, 2011·Journal of Molecular Evolution·Teunis J P van DamBerend Snel
Nov 15, 2011·Cell·Noboru Mizushima, Masaaki Komatsu
May 9, 2012·Trends in Plant Science·Roeland L BerendsenPeter A H M Bakker
Mar 8, 2013·Autophagy·Agnes BánrétiYacine Graba
Feb 25, 2014·Molecular Cell·Guillermo MariñoGuido Kroemer
Mar 13, 2014·International Journal of Biometeorology·L M ManiciM Donatelli
Mar 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cameron WaggMarcel G A van der Heijden
Sep 17, 2014·The Kaohsiung Journal of Medical Sciences·P Saravana KumarS Ignacimuthu
Feb 26, 2016·Annual Review of Plant Biology·Thomas DobrenelChristian Meyer
Apr 29, 2016·Genome Medicine·Jason Lloyd-PriceCurtis Huttenhower
Jul 29, 2017·Nature Reviews. Cancer·Jean M Mulcahy LevyAndrew Thorburn
Aug 25, 2017·Nature Microbiology·Jesse R ZaneveldRebecca Vega Thurber
Oct 2, 2017·Trends in Biochemical Sciences·Dominique Helmlinger, László Tora
Oct 12, 2017·MBio·Katarzyna B Hooks, Maureen A O'Malley
Jan 13, 2018·Cancers·Mathieu PaquetteArnim Pause
Jan 23, 2018·PLoS Pathogens·Guangfei TangZhonghua Ma
Jul 25, 2018·Nature Microbiology·Katharina TrunkSarah J Coulthurst
Oct 6, 2018·Science·Maria G Dominguez BelloMartin J Blaser
Dec 31, 2018·Applied Microbiology and Biotechnology·Oluwaseyi Samuel Olanrewaju, Olubukola Oluranti Babalola

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Citations

Aug 17, 2021·Environmental Microbiology·Jing WangZhonghua Ma
Nov 27, 2021·Applied Biochemistry and Biotechnology·Zihan SunZuoming Nie

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