Abstract
To determine the characteristics of pediatric liver transplant recipients who develop GI and/or PTDM, data on children undergoing their first liver transplant from the SPLIT database were analyzed (n = 1611). Recipient and donor characteristics that were evaluated included age at transplant, gender, race, primary disease, hospitalization status at transplant, BMI, recipient and donor CMV status, donor type, donor age, and primary immunosuppression. GI/PTDM was found in 214 individuals (13%) of whom 166 (78%) were diagnosed within 30 days of transplantation (early GI/PTDM). Multivariate analyses suggests that age >5 yr at transplant, hospitalization at transplant, a primary diagnosis other than BA, early steroid use, and tacrolimus use are associated with increased incidence of early GI. Routine monitoring for the development of GI and post-transplant diabetes is indicated in the short- and long-term care of children after liver transplantation.
References
Sep 1, 1987·Transplantation·J P BoudreauxD S Fryd
Mar 4, 1998·Transplantation·A M MilesE A Friedman
Mar 24, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K MidtvedtB L Bjerkely
Jan 14, 1999·Diabetes Research and Clinical Practice·K YoshiokaS Fujii
Mar 30, 1999·Transplantation·R ShapiroT E Starzl
Feb 24, 2001·Transplantation·J A PaolilloS A Webber
Jul 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M G Nieuwenhuis, J H Kirkels
Oct 2, 2001·Transplantation·A Al-UzriR A Cohn
Jan 17, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Louise C GreenspanRobert S Mathias
Mar 9, 2002·Transplantation·M Roy FirstRon Shapiro
Jul 9, 2002·Liver·Peter T DonaldsonDympna Kelley
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Eba H HathoutLeonard L Bailey
Jan 25, 2005·Therapeutic Drug Monitoring·A M James ShapiroNorman M Kneteman
Dec 24, 2005·Diabetes Care·UNKNOWN American Diabetes Association
Jan 3, 2006·Journal of the American College of Cardiology·Roldano ScognamiglioAngelo Avogaro
Citations
Apr 29, 2014·Transplantation Proceedings·J M ChoS G Lee
Jan 14, 2012·The Journal of Pediatrics·Molly O RegelmannRobert Rapaport
Dec 21, 2010·Transplantation Proceedings·G S BoraD Bhowmik
Apr 8, 2010·Pediatric Clinics of North America·Monique ChoquetteKathleen M Campbell
Apr 8, 2010·Pediatric Clinics of North America·Binita M Kamath, Kim M Olthoff
May 31, 2013·Pediatric Transplantation·Estella M AlonsoUNKNOWN Studies of Pediatric Liver Transplantation (SPLIT) Research Group
Oct 30, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hung-Tien KuoSuphamai Bunnapradist
May 21, 2011·Pediatric Diabetes·A ProkaiA J Szabo
Feb 12, 2011·Pediatric Transplantation·Christopher LaRosaKevin E C Meyers
May 30, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emily Rothbaum PeritoPhilip Rosenthal
Nov 20, 2012·Pediatric Transplantation·Ritika R Kapoor
Aug 22, 2012·Pediatric Transplantation·Fenella GreigNanda Kerkar
Nov 19, 2011·Pediatric Transplantation·Emily Rothbaum PeritoPhilip Rosenthal
Jan 21, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·R H J BandsmaV L Ng
Jun 3, 2015·Pediatric Transplantation·Molly O RegelmannRonen Arnon
Apr 9, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Andrea Kelly, Antoinette Moran
Dec 24, 2011·The Journal of Pediatrics·Vicky L NgUNKNOWN Studies of Pediatric Liver Transplantation (SPLIT) Research Group
Feb 14, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Meheret AsfawAnita M Nucci
Aug 24, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sandy Feng, John Bucuvalas
Jul 31, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rahul ChanchlaniRulan S Parekh
Oct 15, 2011·Journal of Gynecologic Oncology·Na-Rae KimHyun Yee Cho
Jan 31, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A Jay FreemanDaniel H Leung
Jul 10, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Deirdre A KellyUNKNOWN American Society of Transplantation
Sep 28, 2013·Expert Review of Gastroenterology & Hepatology·Denis DevictorUNKNOWN Bicêtre Hospital Pediatric Transplant Group
Jan 1, 2015·Global Pediatric Health·Jiro AbeIchiro Kobayashi
May 25, 2011·Annals of Surgery·Sue V McDiarmidGeorge Mazariegos
Oct 24, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rahul ChanchlaniRulan S Parekh
Sep 27, 2019·Frontiers in Neurology·Valeria CalcaterraGloria Pelizzo
Oct 8, 2020·Pediatric Transplantation·Voytek SlowikBernadette E Vitola
Aug 26, 2018·Gastroenterology·Sandy FengAlberto Sanchez-Fueyo