Post-transplant relapse of therapy-related MDS as gastric myeloid sarcoma: Case report and review of literature.

Leukemia Research Reports
Amy SongMohammad O Hussaini

Abstract

Myelodysplastic syndrome (MDS) are hematologic neoplasms characterized by morphologic dysplasia and ineffective hematopoiesis in the bone marrow. The only potentially curative therapy is stem cell transplant. However, relapse remains a major challenge and is seen in about 25-40% of cases. Myeloid sarcoma presenting as relapse post allogeneic transplant for myeloid neoplasms is rare. We report the sentinel case of a patient with MDS who relapsed as gastric myeloid sarcoma 1 ½ years after allogeneic stem cell transplant. Sixty-nine-year-old male who was diagnosed with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in 2006 and transitional cell bladder carcinoma in 2008. In 2011, he developed therapy-related myeloid neoplasm t(7;22) and no excess blasts. He was treated with Vidaza followed by a MUD hematopoietic stem cell transplant on 8/24/2012. In 2013 the patient developed anorexia and gastric biopsies showed severe gastritis. Repeat gastric biopsy on 02/05/2014 showed an extensive mononuclear infiltrate which could easily be confused with lymphocytes but staining showed myeloid sarcoma. Marrow was negative. The patient remained refractory to therapy and expired 08/10/2016. In summary, we report the first cas...Continue Reading

References

Sep 28, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luca MalcovatiMario Cazzola
Nov 2, 2007·Diagnostic Pathology·Borislav A AlexievXianfeng F Zhao
Jul 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrice ChevallierJean-Luc Harousseau
Jul 17, 2009·British Journal of Haematology·Theo de WitteUNKNOWN European Blood and Marrow Transplantation Group (EBMT), Chronic Leukemia Working Party (CLWP)-MDS subcommittee
Feb 9, 2010·The Tohoku Journal of Experimental Medicine·Toshihiko AndoYukio Tanizawa
May 29, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Satoshi YoshiharaHiroyasu Ogawa
Oct 1, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gita ThanarajasingamPhilippe Armand
Dec 7, 2013·Clinical Lymphoma, Myeloma & Leukemia·Betul OranRichard Champlin
Mar 28, 2017·Clinical Lymphoma, Myeloma & Leukemia·L Max AlmondAnant Desai

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