Post-transplantation hepatocellular carcinoma recurrence: Patterns and relation between vascularity and differentiation degree

World Journal of Hepatology
Annarita PecchiPietro Torricelli

Abstract

To evaluate the relationship between hepatocellular carcinoma (HCC) vascularity and grade; to describe patterns and vascular/histopathological variations of post-transplantation recurrence. This retrospective study included 165 patients (143 men, 22 women; median age 56.8 years, range 28-70.4 years) transplanted for HCC who had a follow-up period longer than 2 mo. Pre-transplantation dynamic computed tomography or magnetic resonance examinations were retrospectively reviewed, classifying HCC imaging enhancement pattern into hypervascular and hypovascular based on presence of wash-in during arterial phase. All pathologic reports of the explanted livers were reviewed, collecting data about HCC differentiation degree. The association between imaging vascular pattern and pathological grade was estimated using the Fisher exact test. All follow-up clinical and imaging data were reviewed for evidence of recurrence. Recurrence rate was calculated and imaging features of recurrent tumor were collected, classifying early and late recurrences based on timing (< or ≥ 2 years after transplantation) and intrahepatic, extrahepatic and both intrahepatic and extrahepatic recurrences based on location. All intrahepatic recurrences were classifie...Continue Reading

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Citations

Oct 16, 2015·Nature Reviews. Gastroenterology & Hepatology·Kymberly D Watt
Nov 18, 2015·World Journal of Gastroenterology : WJG·Jian-Jun GaoWei Tang
Nov 18, 2015·World Journal of Gastroenterology : WJG·René FahrnerFalk Rauchfuß
Dec 21, 2018·World Journal of Gastroenterology : WJG·Kin Pan Au, Kenneth Siu Ho Chok
Nov 12, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elizabeth C VernaFrancis Y Yao
Mar 17, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yi YangYi Chen

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