Post-traumatic stress in pregnant women with primary cytomegalovirus infection and risk of congenital infection in newborns

BJPsych Open
Francesco VadiniGiustino Parruti

Abstract

Substantial evidence indicates that perinatal mental disturbances are associated with the risk for negative maternal-newborn outcomes. A neuroendocrine brain-placenta interaction has been described to explain the association between prenatal stress-related disorders and placental abnormalities. Whether these mechanisms may affect the likelihood of mother-to-child transmission (MTCT) of infections has never been investigated. To evaluate the role of psychological factors in cytomegalovirus (CMV) MTCT in pregnant women with primary CMV infection. A cohort of 276 pregnant women with primary CMV infection underwent assessment of (a) reactive psychopathological symptoms, such as current depressive symptoms and ongoing symptoms of post-traumatic stress disorder; and (b) stable personality traits, such as alexithymia and Type D (distressed) personality. Congenital infection was diagnosed by CMV DNA amplification from blood and/or urine and saliva from newborn at birth. The occurrence of congenital CMV disease in the newborn was independently predicted by post-traumatic stress symptoms during pregnancy. Our findings suggest that psychological stress-related disturbances may weaken the physical and immunological barrier against the moth...Continue Reading

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Citations

Jan 18, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Mônica Custódia do Couto Abreu PamplonaRicardo Ishak
Nov 11, 2019·Pharmacological Reports : PR·Małgorzata KowalczykPiotr Gałecki

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT01659684

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