Post-treatment vascular leakage and inflammatory responses around brain cysts in porcine neurocysticercosis

PLoS Neglected Tropical Diseases
Siddhartha MahantyCysticercosis Working Group in Peru

Abstract

Cysticidal treatment of neurocysticercosis, an infection of humans and pig brains with Taenia solium, results in an early inflammatory response directed to cysts causing seizures and focal neurological manifestations. Treatment-induced pericystic inflammation and its association with blood brain barrier (BBB) dysfunction, as determined by Evans blue (EB) extravasation, was studied in infected untreated and anthelmintic-treated pigs. We compared the magnitude and extent of the pericystic inflammation, presence of EB-stained capsules, the level of damage to the parasite, expression of genes for proinflammatory and regulatory cytokines, chemokines, and tissue remodeling by quantitative PCR assays between treated and untreated infected pigs and between EB-stained (blue) and non stained (clear) cysts. Inflammatory scores were higher in pericystic tissues from EB-stained cysts compared to clear cysts from untreated pigs and also from anthelmintic-treated pigs 48 hr and 120 hr after treatment. The degree of inflammation correlated with the severity of cyst wall damage and both increased significantly at 120 hours. Expression levels of the proinflammatory genes for IL-6, IFN-γ, TNF-α were higher in EB-stained cysts compared to clear cy...Continue Reading

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Citations

Feb 7, 2016·Asian Pacific Journal of Tropical Medicine·Syed A A RizviSultan S Ahmed
Jan 30, 2016·Parasite Immunology·I GonzalesUNKNOWN Cysticercosis Working Group in Peru
Dec 17, 2015·Parasite Immunology·A FleuryE Sciutto
Jun 3, 2017·PLoS Neglected Tropical Diseases·Carla CangalayaUNKNOWN Cysticercosis Working Group in Peru
Jun 13, 2018·The American Journal of Tropical Medicine and Hygiene·Karen A Alroy For The Cysticercosis Working Group In Peru
Jan 5, 2019·The American Journal of Tropical Medicine and Hygiene·Theodore E NashSiddhartha Mahanty
Nov 16, 2018·Parasitology·Anja de LangeJoseph V Raimondo
Apr 6, 2018·BioMed Research International·Giuseppe A RamirezLorenzo Dagna
Dec 1, 2017·PLoS Neglected Tropical Diseases·Siddhartha MahantyUNKNOWN Cysticercosis Working Group in Peru
Dec 15, 2015·PLoS Neglected Tropical Diseases·Carla CangalayaUNKNOWN Cysticercosis Working Group in Peru
Apr 28, 2021·PLoS Neglected Tropical Diseases·Rogger P Carmen-OrozcoUNKNOWN Cysticercosis Working Group in Peru

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Methods Mentioned

BETA
PCR

Software Mentioned

AxioVision
Prism

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